N,N-Diethyl-1,1-dimethyl-2-butinylamin | 91015-74-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-Diethyl-1,1-dimethyl-2-butinylamin
• 英文别名: N,N-diethyl-2-methyl-3-pentyn-2-amine；N,N-diethyl-2-methylpent-3-yn-2-amine
• CAS: 91015-74-6
• 化学式: C₁₀H₁₉N
• 分子量: 153.268
• InChiKey: VUFJCQCMESDOSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS<br/>[FR] COMPOSÉS POUR INHIBER LA PROLIFÉRATION CELLULAIRE DANS LES CANCERS INDUITS PAR L'EGFR
  申请人：ARIAD PHARMA INC

  公开号：WO2013169401A1

  公开（公告）日：2013-11-14

  The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of Formula (I), wherein the variables are as defined herein.

  这项发明涉及化合物、药物组合物和治疗EGFR驱动的Formula (I)癌症患者的方法，其中变量如本文所定义。
• PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Genentech, Inc.

  公开号：EP2046799B1

  公开（公告）日：2017-07-19
• THIAZOLOPYRIMIDINE P13K INHIBITOR COMPOUNDS AND METHODS OF USE
  申请人：Genentech, Inc.

  公开号：EP2207781B1

  公开（公告）日：2012-11-28
• METHODS AND COMPOSITIONS FOR RAF KINASE MEDIATED DISEASES
  申请人：ARIAD Pharmaceuticals, Inc.

  公开号：US20150166591A1

  公开（公告）日：2015-06-18

  The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of Formula (I), wherein the variables are as defined herein.
• Compounds for Inhibiting Cell Proliferation in EGFR-Driven Cancers
  申请人：ARIAD Pharmaceuticals, Inc.

  公开号：US20160244469A1

  公开（公告）日：2016-08-25

  The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of Formula I: wherein the variables are as defined herein.