acrylamidoethylphosphorylcholine | 163674-35-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: acrylamidoethylphosphorylcholine
• 英文别名: 2-(acryloylamino)ethyl 2-(trimethylammonio)ethyl phosphate；2-(Prop-2-enoylamino)ethyl 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 163674-35-9
• 化学式: C₁₀H₂₁N₂O₅P
• 分子量: 280.261
• InChiKey: MPWWERGGOFIWJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  87.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,2-Dihydroxyethyl 2-(trimethylazaniumyl)ethyl phosphate 、 丙烯酰胺 在 dimethylamine borane 作用下， 以 甲醇 为溶剂， 反应 7.0h， 生成 acrylamidoethylphosphorylcholine
  参考文献：
  名称：

  一种低成本磷脂聚合单体及其制备方法

  摘要：

  本发明公开了一种低成本磷脂聚合单体及其制备方法。本申请磷脂聚合单体的制备方法成本低、反应条件温和、污染小；制备所得磷脂聚合单体可进一步聚合得到具有仿生物磷脂结构的聚合物，同时也可以改善聚合物体系的热稳定性和润湿性，提高聚合物乳液在金属基材上的附着力和耐腐蚀性能。

  公开号：

  CN114524842A

文献信息

• Treating solution for contact lenses
  申请人：NOF CORPORATION

  公开号：EP0537972A1

  公开（公告）日：1993-04-21

  A highly hydrous soft contact lens comprising a copolymer which contains as an ingredient a monomer having constitution similar to that of phospholipid represented by the following general formula: wherein X is and R₁ is hydrogen or methyl, Y is -CH₂-, -CH₂-O-, -CH₂CH₂-O-, -CH₂CH₂CH₂-O-, or -CH₂CH₂CH₂CH₂-O-, n is an integer of 1-20, and, R₂, R₃ and R₄ are the same or different groups and alkyl or hydroxyalkyl of 1-8 carbon atoms. Further, a treating solution for contact lenses which comprises a polymer containing as an ingredient the above monomer and a solvent which can dissolve the polymer.

  一种高保湿软性隐形眼镜，由一种共聚物组成，该共聚物的成分中含有一种单体，该单体的组成与磷脂相似，其通式如下： 其中 X 是 和 R₁ 是氢或甲基，Y 是 -CH₂-，-CH₂-O-，-CH₂CH₂-O-，-CH₂CH₂CH₂-O-、 或-CH₂CH₂CH₂CH₂-O-、 n 是 1-20 的整数，并且，R₂、R₃ 和 R₄ 是相同或不同的基团和 1-8 个碳原子的烷基或羟烷基。 此外，一种隐形眼镜护理液，其成分包括含有上述单体的聚合物和可溶解聚合物的 溶剂。
• POLYSACCHARIDE-BASED GRAFT COPOLYMER AND COMPOSITION COMPRISING SAME FOR PERSONAL CARE
  申请人：Kci Limited

  公开号：EP2660252A2

  公开（公告）日：2013-11-06

  The present invention relates to a graft copolymer including a polysaccharide as a main chain and a phosphorylcholine analogous group-containing monomer as a side chain, and a composition for skin and hair care including the copolymer as an active ingredient. The graft copolymer according to the present invention exhibits more improved moisturizing capacity and better biocompatibility than the existing polysaccharide-based graft copolymer by introducing a phosphorylcholine analogous group-containing compound, and accordingly, the composition for hair and skin care including the same also has improved moisturizing capacity, protection capacity of damaged hair, skin affinity, a skin barrier function, and the like.

  本发明涉及一种包括作为主链的多糖和作为侧链的含磷酸胆碱类似基团单体的接枝共聚物，以及一种包括该共聚物作为活性成分的护肤和护发组合物。根据本发明的接枝共聚物通过引入含磷酸胆碱类似基团的化合物，比现有的多糖基接枝共聚物具有更高的保湿能力和更好的生物相容性，相应地，包括本发明的接枝共聚物的护发护肤组合物也具有更高的保湿能力、对受损头发的保护能力、皮肤亲和性、皮肤屏障功能等。
• SURFACE-MODIFIED ULTRAVIOLET BLOCKING POWDER AND ULTRAVIOLET BLOCKING COMPOSITION INCLUDING SAME
  申请人：KCI Co.,ltd

  公开号：EP2772247A1

  公开（公告）日：2014-09-03

  The present invention relates to a surface-modified ultraviolet blocking powder obtained by reacting an ultraviolet blocking powder including a chloroacetyl group, a phospholipid monomer including an unsaturated bonding, and a catalyst inducing the reaction of the chloroacetyl group and the unsaturated bonding. According to the surface-modified ultraviolet blocking powder of the present invention, the surface may be modified using an effective method, and through chemical bonding (covalent bonding) and as a result of surface modification, the stability of the powder is high. In addition, since the surface modification is performed by using a biocompatible component, the ultraviolet blocking composition including the surface-modified ultraviolet blocking powder may provide ultraviolet blocking properties and biocompatibility at the same time.

  本发明涉及一种表面改性紫外线阻挡粉末，该粉末由包括氯乙酰基的紫外线阻挡粉末、包括不饱和键的磷脂单体和诱导氯乙酰基与不饱和键反应的催化剂反应而得。根据本发明的表面改性紫外线阻隔粉末，可以使用有效的方法对表面进行改性，通过化学键（共价键）和表面改性的结果，粉末的稳定性很高。此外，由于表面改性是通过使用生物相容性成分进行的，因此包括表面改性紫外线阻挡粉末在内的紫外线阻挡组合物可以同时提供紫外线阻挡特性和生物相容性。
• Hydrophilic copolymer with one thiol-containing terminal group
  申请人：Novartis AG

  公开号：US10287370B2

  公开（公告）日：2019-05-14

  The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

  本发明涉及一类亲水聚合物，每种聚合物都包含一个唯一的含硫醇末端基团。这种亲水聚合物在加热时对含氮杂环丁烷聚合物的氮杂环丁烷基团具有高活性，特别适用于生产水溶性高支链亲水聚合物材料，可用于生产水梯度隐形眼镜。
• Hydrophilic copolymer with pendant thiol groups
  申请人：Novartis AG

  公开号：US10618986B2

  公开（公告）日：2020-04-14

  The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

  本发明涉及一类亲水共聚物，该共聚物由松散悬挂的含硫醇悬垂基团组成。这种亲水共聚物在加热时对含氮杂环丁烷聚合物的氮杂环丁烷基团具有高活性，特别适用于生产水溶性高支链亲水聚合物材料，可用于生产水梯度隐形眼镜。