5'-O-(4,4'-Dimethoxytrityl)-N2-phenoxyacetyl-2'-deoxyguanosine-3'-O-succinate | 118533-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-(4,4'-Dimethoxytrityl)-N2-phenoxyacetyl-2'-deoxyguanosine-3'-O-succinate
• 英文别名: 4-[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-[6-oxo-2-[(2-phenoxyacetyl)amino]-1H-purin-9-yl]oxolan-3-yl]oxy-4-oxobutanoic acid
• CAS: 118533-24-7
• 化学式: C₄₃H₄₁N₅O₁₁
• 分子量: 803.825
• InChiKey: DPNDOBMBTBULGR-GABYNLOESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  59
• 可旋转键数：
  18
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  198
• 氢给体数：
  3
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  5'-O-(4,4'-Dimethoxytrityl)-N2-phenoxyacetyl-2'-deoxyguanosine-3'-O-succinate 、 1,6-己二异氰酸酯 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Synthesis of Oligodeoxyribonucleoside Methylphosphonates Containing 2-Aminopurine

  摘要：

  Oligodeoxyribonucleoside methylphosphonates containing multiple 2-aminopurine bases were synthesized by solid-phase phosphonamidite chemistry for investigating their triple helix formation with natural DNA or other duplex targets and for cellular uptake studies of the methylphosphonate oligomers. The base-labile phenoxyacetyl group was used as the N-2-amino protecting group for 2-aminopurine, allowing the final deprotection of the oligomers to be performed under the standard ethylenediamine condition.

  DOI：

  10.1080/07328319608002463
• 作为产物：
  描述：

  5-O-(4,4-二甲氧基三苯甲游基)-2-脱氧鸟苷 在 4-二甲氨基吡啶 、 水 、 三乙胺 作用下， 以 吡啶 、 1,2-二氯乙烷 、 三乙胺 为溶剂， 反应 3.0h， 生成 5'-O-(4,4'-Dimethoxytrityl)-N2-phenoxyacetyl-2'-deoxyguanosine-3'-O-succinate
  参考文献：
  名称：

  Synthesis of Oligodeoxyribonucleoside Methylphosphonates Containing 2-Aminopurine

  摘要：

  Oligodeoxyribonucleoside methylphosphonates containing multiple 2-aminopurine bases were synthesized by solid-phase phosphonamidite chemistry for investigating their triple helix formation with natural DNA or other duplex targets and for cellular uptake studies of the methylphosphonate oligomers. The base-labile phenoxyacetyl group was used as the N-2-amino protecting group for 2-aminopurine, allowing the final deprotection of the oligomers to be performed under the standard ethylenediamine condition.

  DOI：

  10.1080/07328319608002463