3-Isobutyl-pentamethylensulfid | 18437-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: 3-Isobutyl-pentamethylensulfid
• 英文别名: 3-(2-Methylpropyl)thiane
• CAS: 18437-86-0
• 化学式: C₉H₁₈S
• 分子量: 158.308
• InChiKey: QSPNYDLOXCJTSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• TAM FAMILY KINASE /AND CSF1R KINASE INHIBITOR AND USE THEREOF
  申请人：Nanjing Transthera Biosciences Co., Ltd.

  公开号：US20210177828A1

  公开（公告）日：2021-06-17

  The present invention provides a novel inhibitor compound of general formula (I), exhibiting excellent kinase inhibitor activity. The compound of the present invention can be used to prevent and/or treat diseases mediated by abnormal expression of TAM family kinase receptors and/or ligands thereof. In addition, the compound of the present invention can also target CSF1R kinase, and thus can be used to prevent and/or treat diseases mediated by abnormal expression of TAM family kinase receptors and/or CSF1R kinase receptors and/or ligands thereof.
• FGFR INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：BridGene Biosciences, Inc.

  公开号：US20220218703A1

  公开（公告）日：2022-07-14

  The disclosure provides novel FGFR inhibitors based on the pyridinylpyrimidine. The disclosure includes inhibitors with broad inhibitory activity against all FGFR isoforms, and inhibitors with selective inhibition against FGFR4. These novel pyridinylpyrimidine-based FGFR inhibitors, or their derivatives, have strong potential to be used to treat cancer.