7-methoxy-1-(2-(4-(((6-oxido-2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-yl)methyl)amino)piperidin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one | 959614-95-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-methoxy-1-(2-(4-(((6-oxido-2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-yl)methyl)amino)piperidin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one
• 英文别名: 7-Methoxy-1-[2-[4-[(6-oxido-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-6-ium-7-yl)methylamino]piperidin-1-yl]ethyl]-1,5-naphthyridin-2-one
• CAS: 959614-95-0
• 化学式: C₂₄H₂₉N₅O₅
• 分子量: 467.525
• InChiKey: KMNGNXMPPGXCCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF
  申请人：Kiyoto Taro

  公开号：US20090198063A1

  公开（公告）日：2009-08-06

  Disclosed is a compound represented by the general formula: [wherein R 1 represents an aryl or heterocyclic group which may be substituted or the like; X 1 represents a C 2 -C 4 alkylene group or the like; X 2 , X 3 and X 5 independently represent NH, a bond or the like; X 4 represents a lower alkylene group, a bond or the like; Y 1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and Z 6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z 3 , Z 4 , Z 5 and Z 6 represents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

  本发明涉及一种化合物，其通式表示为：[其中，R1代表取代的芳基或杂环基等；X1代表C2-C4烷基或类似基团；X2、X3和X5独立地代表NH、键或类似基团；X4代表低级烷基烷基或键或类似基团；Y1代表可取代的二价脂环烃残基或可取代的二价脂环胺基残基；Z1、Z2、Z3、Z4、Z5和Z6独立地代表氮原子、式为CH的基团或类似基团，但至少其中之一的Z3、Z4、Z5和Z6代表氮原子]或其盐，其作为一种抗菌剂具有应用价值。
• US8211908B2
  申请人：——

  公开号：US8211908B2

  公开（公告）日：2012-07-03