3-(3,4-dichloro-benzyl)-1-methyl-6-(3-phenyl-prop-1-ynyl)-1H-quinazoline-2,4-dione | 515869-82-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(3,4-dichloro-benzyl)-1-methyl-6-(3-phenyl-prop-1-ynyl)-1H-quinazoline-2,4-dione
• 英文别名: 3-[(3,4-Dichlorophenyl)methyl]-1-methyl-6-(3-phenylprop-1-ynyl)quinazoline-2,4-dione
• CAS: 515869-82-6
• 化学式: C₂₅H₁₈Cl₂N₂O₂
• 分子量: 449.336
• InChiKey: XIUZFFKIODFOJH-UHFFFAOYSA-N

物化性质

• 沸点：
  635.2±65.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Alkynylated fused ring pyrimidine compounds
  申请人：——

  公开号：US20030130278A1

  公开（公告）日：2003-07-10

  A compound selected from those of formula (I): 1 wherein W 1 represents O, S, or —NR 3 in which R 3 represents hydrogen, alkyl, OH or CN; W 2 represents a group selected from hydrogen, CF 3 , NH 2 , monoalkylamino, dialkylamino, alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkylalkyl, heterocycle, these groups being optionally substituted, or W 1 and W 2 form together a group of formula —N═X 4 —W 3 — as defined in the description, X 1 , X 2 and X 3 represent N or C optionally substituted, n is 0 to 8, Z represents —CR 12 R 13 , wherein R 12 and R 13 are as defined in the description, A represents a ring system, the groups R 2 represent hydrogen or various chemical groups as defined in the description, q is 0 to 7; R 1 represents hydrogen, alkyl, alkenyl, alkynyl, or a ring system, and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix metalloprotease.

  从公式（I）中选择的一种化合物：其中W1代表O、S或—NR3，其中R3代表氢、烷基、OH或CN；W2代表从氢、CF3、NH2、单烷基氨基、二烷基氨基、烷基、烯基、炔基、芳基、芳基烷基、环烷基烷基、杂环烷基中选择的一个基团，这些基团可以选择性地被取代，或者W1和W2一起形成一个公式为—N═X4—W3—的基团，如描述中定义的，X1、X2和X3代表N或C，可以选择性地被取代，n为0到8，Z代表—CR12R13，其中R12和R13如描述中定义，A代表一个环系统，基团R2代表氢或描述中定义的各种化学基团，q为0到7；R1代表氢、烷基、烯基、炔基或一个环系统，以及其光学异构体、N-氧化物和与药学上可接受的酸或碱形成的加合物，以及含有它们的药用产品作为特异性抑制剂对13型基质金属蛋白酶具有用处。
• Aqueous room temperature living radical polymerization of vinyl halides
  申请人：UNIVERSITY OF PENNSYLVANIA

  公开号：US20030078353A1

  公开（公告）日：2003-04-24

  A living polymerization process for preparation of poly(vinyl chloride) (PVC) with controlled molecular weight and molecular weight distribution is described. The polymerization reaction can be initiated by various polyhalocarbon initiators in conjunction with non-metallic reducing single electron transfer reagents as catalysts and accelerated by electron shuttles. The process occurs at room temperature in water or water-organic solvent medium. The polymerization provides PVC with a controlled molecular weight and narrow molecular weight distribution. The halogen containing polymer compositions are useful as, among others, viscosity modifiers, impact modifiers and compatibilizers.

  本文介绍了一种用于制备具有可控分子量和分子量分布的聚氯乙烯（PVC）的活聚合工艺。聚合反应可由各种聚卤烃引发剂与作为催化剂的非金属还原单电子转移试剂共同引发，并由电子梭加速。该过程在室温下于水或水有机溶剂介质中进行。聚合反应可使聚氯乙烯具有可控的分子量和较窄的分子量分布。含卤聚合物组合物可用作粘度调节剂、抗冲击调节剂和相容剂等。
• ALKYNYLATED FUSED RING PYRIMIDINE COMPOUNDS AS MATRIX METALLOPROTEASE-13 INHIBITORS
  申请人：Warner-Lambert Company LLC

  公开号：EP1465878A1

  公开（公告）日：2004-10-13
• US6838535B2
  申请人：——

  公开号：US6838535B2

  公开（公告）日：2005-01-04
• US6911515B2
  申请人：——

  公开号：US6911515B2

  公开（公告）日：2005-06-28