methyl 2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]ethyl amine | 947617-29-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: methyl 2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]ethyl amine
• 英文别名: 2-[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]oxy-N-methylethanamine
• CAS: 947617-29-0
• 化学式: C₇H₈F₉NO
• 分子量: 293.132
• InChiKey: HDLHUCIJUWSUHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-(perfluoro-tert-butyloxy) ethyl tosylate 、 甲胺 反应 17.0h， 以69%的产率得到methyl 2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]ethyl amine
  参考文献：
  名称：

  氟化学中的新一代马尾辫：伯，仲和叔（九氟叔丁基丁氧基）乙胺的合成

  摘要：

  （Nonafluoro-叔-butyloxy）乙基甲苯磺酸酯4以65％的产率制备从nonafluoro-叔丁醇1使用市售试剂。4与HNR 1 R 2的进一步反应（R 1  = R 2  = H，CH 3 ; R 1  = H，R 2  = CH 3，（CH 2）3 C 8 F 17，CH 2 CH 2 OC（CF 3）3）提供适当的（CF 3）3种COCH 2 CH 2 NR 1 R 2胺，产率20-69％。的改进的总产率[（CF 3）3 COCH 2 CH 2 ] 3- Ñ NR Ñ至1由反应得到的（CF 3）3 CONA 2和（XCH 2 CH 2）3- Ñ NR Ñ（X = Cl，n  = 0，1，2，R = CH 3 ; X = CH 3 SO 2 O，n ＝ 1，R ＝ CH 3 SO 2）氮芥和类似的反应性β-取代的乙胺。标题胺是可流动的无色液体，在蒸汽中易挥发。庞大的氟马尾辫（CF

  DOI：

  10.1016/j.jfluchem.2006.06.020

文献信息

• Compounds and methods for trans-membrane delivery of molecules
  申请人：Aposense LTD.

  公开号：US10195286B2

  公开（公告）日：2019-02-05

  A conjugate for delivery of drugs, such as genetic drugs, [e.g., siRNA, dsiRNA, or antisense oligonucleotides (ASO)] across biological membranes is provided. The conjugates of the Invention are capable of delivering drugs in both presence and absence of plasma proteins.

  本发明提供了一种用于跨生物膜递送药物（如基因药物）[如 siRNA、dsiRNA 或反义寡核苷酸 (ASO)]的共轭物。本发明的共轭物能够在存在或不存在血浆蛋白的情况下递送药物。
• COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
  申请人：Aposense Ltd.

  公开号：US20170037401A1

  公开（公告）日：2017-02-09

  A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.
• US9993563B2
  申请人：——

  公开号：US9993563B2

  公开（公告）日：2018-06-12
• [EN] COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES<br/>[FR] COMPOSÉS ET PROCÉDÉS D'ADMINISTRATION TRANSMEMBRANAIRE DE MOLÉCULES
  申请人：APOSENSE LTD

  公开号：WO2017029664A1

  公开（公告）日：2017-02-23

  A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.