1,3-Benzothiazole-2,6-diamine dihydrochloride | 181070-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 1,3-Benzothiazole-2,6-diamine dihydrochloride
• 英文别名: 1,3-benzothiazole-2,6-diamine;dihydrochloride
• CAS: 181070-25-7
• 化学式: C7H9Cl2N3S
• 分子量: 238.14
• InChiKey: VJCSNAYBQVVCAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.2
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Method for treating fibrotic diseases or other indications IC
  申请人：Alteon, Inc.

  公开号：US20020068729A1

  公开（公告）日：2002-06-06

  Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 1

  提供了一种处理、改善或预防动物包括人类发明的指示的方法，包括给予公式I的化合物的有效量：1
• Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
  申请人：——

  公开号：US20020022622A1

  公开（公告）日：2002-02-21

  Provided are, among other things, compounds of formula I or IA, 1 . Also provided are methods of treatment with such compounds.

  提供的是公式I或IA,1的化合物，以及使用这些化合物进行治疗的方法。
• Method for treating glaucoma IIB
  申请人：——

  公开号：US20020119970A1

  公开（公告）日：2002-08-29

  Provided is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure decreasing amount or ocular accommodation improving amount of a compound of the formula I or IA, 1 wherein J is oxygen, sulfur, or N—R d .

  提供了一种降低动物（包括人类）眼内压或改善眼睛调节的方法，包括给予化合物I或IA的一定量，其中J是氧、硫或N-Rd。
• Methods of Treating or Preventing Cardiac Disease Associated With a High Fat Diet
  申请人：Thomas Merlin

  公开号：US20090088461A1

  公开（公告）日：2009-04-02

  The present invention relates to a method of treating or preventing cardiac disorders, myocardial inflammation or myocardial oxidative stress associated with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention. The present invention also relates to a method of ameliorating weight gain, myocardial AGE accumulation associated, mitochondrial superoxide production, RAGE expression or PPARα expression with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention.

  本发明涉及一种使用该发明的噻唑类化合物和组合物治疗或预防与高脂饮食相关的心脏疾病、心肌炎症或心肌氧化应激的方法。本发明还涉及一种使用该发明的噻唑类化合物和组合物改善与高脂饮食相关的体重增加、心肌AGE积累、线粒体超氧化物产生、RAGE表达或PPARα表达的方法。
• Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment
  申请人：——

  公开号：US20020182165A1

  公开（公告）日：2002-12-05

  A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula 1

  一种用于改善生物力学和扩散特性的头发、指甲、离体器官、离体细胞或离体组织的治疗方法和组合物，包括有效量的来自化合物公式1所述化合物组合的化合物。