1,4-Bis(2'-pyrazinyl)piperazine | 64683-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-Bis(2'-pyrazinyl)piperazine
• 英文别名: 2',3',5',6'-tetrahydro-[2,1';4',2'']terpyrazine；2',3',5',6'-Tetrahydro-[2,1';4',2'']terpyrazin；2-(4-Pyrazin-2-ylpiperazin-1-yl)pyrazine
• CAS: 64683-34-7
• 化学式: C₁₂H₁₄N₆
• 分子量: 242.283
• InChiKey: NMISNLLIVULFSC-UHFFFAOYSA-N

物化性质

• 熔点：
  197-198 °C
• 沸点：
  453.2±45.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  哌嗪 、 2-氯吡嗪 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 100.0 ℃ 、800.0 MPa 条件下， 反应 96.0h， 以96%的产率得到1,4-Bis(2'-pyrazinyl)piperazine
  参考文献：
  名称：

  High-pressure functionalization of diaza-crown ethers: new synthesis of silver(1+) ion-specific binders

  摘要：

  High-pressure S(N)Ar reaction was first applied to the synthesis of a new crown ether family, which incorporated various heteroaromatics as potential cation binding sites in a unique fashion. In a CH2Cl2 liquid membrane transport experiment, several diaza-crown ethers having thiazole, oxazole, pyrazine, and pyridazine rings exhibited a perfect Ag+ ion selectivity. Cation extraction and C-13 NMR titration experiments revealed that attachment of a unique heterocycle to the diaza-crown ring, if in the proper position, significantly offered excellent Ag+ ion specificity. Since the binding and transport selectivities of these crown ethers were apparently higher than those with conventional crown ethers, the high-pressure technique provided a useful method for synthesis of a new specific crown ether family.

  DOI：

  10.1021/jo00028a027

文献信息

• 1,4-di (heterocyclic substituted) piperazines
  申请人：AMERICAN CYANAMID CO

  公开号：US02459367A1

  公开（公告）日：1949-01-18