N-[[4-[(2-fluorophenyl)methoxy]-3-methoxyphenyl]methyl]-1,3-benzothiazol-2-amine | 1206541-18-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-[[4-[(2-fluorophenyl)methoxy]-3-methoxyphenyl]methyl]-1,3-benzothiazol-2-amine
• CAS: 1206541-18-5
• 化学式: C₂₂H₁₉FN₂O₂S
• 分子量: 394.469
• InChiKey: LPVGLYHGPAIPHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  71.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] FUSED OXAZOLE AND THIAZOLE DERIVATIVES AS TRPMS MODULATORS<br/>[FR] DÉRIVÉS OXAZOLE ET THIAZOLE FUSIONNÉS EN TANT QUE MODULATEURS DE TRPM8
  申请人：GLENMARK PHARMACEUTICAL S A

  公开号：WO2010010435A2

  公开（公告）日：2010-01-28

  The present invention provides fused oxazole and thiazole derivatives as TRPM8 (Transient Receptor Potential subfamily M, member 8) modulators. In particular, compounds described herein are useful for treating diseases, disorders, conditions modulated by TRPM8. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPM8.