(3R, 8aS)-hexahydro-3-phenyl-8a-p-tolyoxazolo[3,2-a]pyrazin-5-one | 1399859-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (3R, 8aS)-hexahydro-3-phenyl-8a-p-tolyoxazolo[3,2-a]pyrazin-5-one
• CAS: 1399859-36-9
• 化学式: C₁₉H₂₀N₂O₂
• 分子量: 308.38
• InChiKey: LZJLGQRZCMSHRD-PKOBYXMFSA-N

反应信息

• 作为反应物：
  描述：

  (3R, 8aS)-hexahydro-3-phenyl-8a-p-tolyoxazolo[3,2-a]pyrazin-5-one 在 aluminum (III) chloride 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 、
  参考文献：
  名称：

  Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters

  摘要：

  An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective synthesis in up to 45% overall yield. This is a practical route to optically pure piperazines for medicinal chemistry. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.031
• 作为产物：
  描述：

  (3R, 8aS)-benzylhexahydro-5-oxo-3-phenyl-8a-p-tolyoxazolo[3,2-a]pyrazine-7-carboxylate 在 20% Pd/C 、 氢气 作用下， 以 乙醇 为溶剂， 反应 20.0h， 以92%的产率得到(3R, 8aS)-hexahydro-3-phenyl-8a-p-tolyoxazolo[3,2-a]pyrazin-5-one
  参考文献：
  名称：

  Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters

  摘要：

  An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective synthesis in up to 45% overall yield. This is a practical route to optically pure piperazines for medicinal chemistry. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.031