N-{3-[(4-chlorophenyl)methyl]-4-oxo(3-hydroquinazolin-6-yl)}prop-2-enyloxycarboxamide | 1071464-14-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-{3-[(4-chlorophenyl)methyl]-4-oxo(3-hydroquinazolin-6-yl)}prop-2-enyloxycarboxamide
• 英文别名: prop-2-enyl N-[3-[(4-chlorophenyl)methyl]-4-oxoquinazolin-6-yl]carbamate
• CAS: 1071464-14-6
• 化学式: C₁₉H₁₆ClN₃O₃
• 分子量: 369.807
• InChiKey: HWXQWDDBXMAGQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
  申请人：Koltun Dmitry

  公开号：US20080255161A1

  公开（公告）日：2008-10-16

  The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.

  本发明揭示了3-羟基喹唑啉-4-酮衍生物，用作硬脂酰辅酶A去饱和酶的抑制剂。这些化合物在治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病方面具有用途，特别是与异常脂质水平、癌症、心血管疾病、糖尿病、肥胖、代谢综合征等相关的疾病。
• [EN] 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS<br/>[FR] DÉRIVÉS DE 3-HYDROQUINAZOLIN-4-ONE DESTINÉS À ÊTRE UTILISÉS COMME INHIBITEURS DE STÉAROYL-CoA DÉSATURASE
  申请人：CV THERAPEUTICS INC

  公开号：WO2008127615A1

  公开（公告）日：2008-10-23

  [EN] The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
  [FR] La présente invention concerne des dérivés de 3-hydroquinazolin-4-one destinés à être utilisés comme inhibiteurs de stéaroyl-CoA désaturase. Ces composés sont utiles dans le traitement et/ou la prévention de diverses maladies humaines, médiées par des enzymes stéaroyl-CoA désaturases (SCD), en particulier des maladies liées à des taux de lipides anormaux, le cancer, les maladies cardiovasculaires, le diabète, l'obésité, le syndrome métabolique et similaire.