(E)-4-[2-(2-methanesulfonyl-4-methoxyphenyl)-vinyl]-phenyl acetate | 1226810-21-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-4-[2-(2-methanesulfonyl-4-methoxyphenyl)-vinyl]-phenyl acetate
• 英文别名: [4-[(E)-2-(4-methoxy-2-methylsulfonylphenyl)ethenyl]phenyl] acetate
• CAS: 1226810-21-4
• 化学式: C₁₈H₁₈O₅S
• 分子量: 346.404
• InChiKey: GBGVCNWZGMYDGI-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-4-[2-(2-methanesulfonyl-4-methoxyphenyl)-vinyl]-phenyl acetate 在 吡啶盐酸盐 作用下， 反应 15.0h， 以33%的产率得到(E)-4-[2-(4-hydroxyphenyl)-vinyl]-3-methanesulfonylphenol
  参考文献：
  名称：

  Stilbene analogs as inducers of apolipoprotein-I transcription

  摘要：

  Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4'-Dihydroxy-2-methoxystilbene was the most potent (4.6x more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.076
• 作为产物：
  描述：

  4-乙酰氧基苯乙烯 、 Methyl-(6-brom-3-methoxy-phenyl)-sulfon 在 palladium diacetate 、 N,N-二异丙基乙胺 、 2-(二叔丁基膦)联苯 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以43%的产率得到(E)-4-[2-(2-methanesulfonyl-4-methoxyphenyl)-vinyl]-phenyl acetate
  参考文献：
  名称：

  Stilbene analogs as inducers of apolipoprotein-I transcription

  摘要：

  Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4'-Dihydroxy-2-methoxystilbene was the most potent (4.6x more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.076

文献信息

• Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
  申请人：Wong C.W. Norman

  公开号：US20060205792A1

  公开（公告）日：2006-09-14

  The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

  本公开提供了一些非天然的多酚化合物，这些化合物可以上调载脂蛋白A-I（ApoA-I）的表达。所述的组合物和方法可用于治疗和预防心血管疾病及相关疾病状态，包括胆固醇或脂质相关紊乱，例如动脉粥样硬化。
• Stilbenes and Chalcones for the Prevention and Treatment of Cardiovascular Diseases
  申请人：Wong Norman C.W.

  公开号：US20110082176A1

  公开（公告）日：2011-04-07

  The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

  本公开提供非自然产生的多酚化合物，可以上调载脂蛋白A-I（ApoA-I）的表达。所披露的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关的疾病，例如动脉粥样硬化。
• US7846915B2
  申请人：——

  公开号：US7846915B2

  公开（公告）日：2010-12-07
• US8242144B2
  申请人：——

  公开号：US8242144B2

  公开（公告）日：2012-08-14
• [EN] STILBENES AND CHALCONES FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES<br/>[FR] STILBENES ET CHALCONES UTILISES POUR LA PREVENTION ET LE TRAITEMENT DE MALADIES CARDIO-VASCULAIRES
  申请人：RESVERLOGIX CORP

  公开号：WO2006045010A2

  公开（公告）日：2006-04-27

  [EN] The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
  [FR] La présente invention concerne des composés de polyphénol n'existant pas à l'état naturel qui régulent à la hausse l'expression de l'apolipoprotéine A-I (ApoA-I). Les compostions et méthodes de l'invention conviennent pour le traitement et la prévention de maladies cardio-vasculaires et manifestations pathologiques connexes dont les troubles dus à un excès de cholestérol ou de lipides tels que l'athérosclérose.