4-(chloromethyl)-s-hydrindacene | 65935-64-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4-(chloromethyl)-s-hydrindacene
• 英文别名: 4-chloromethyl-s-hydrindacene；4-Chlormethyl-s-hydrindacen；4-(Chloromethyl)-1,2,3,5,6,7-hexahydro-s-indacene
• CAS: 65935-64-0
• 化学式: C₁₃H₁₅Cl
• 分子量: 206.715
• InChiKey: JXKZRGNDUUGTGF-UHFFFAOYSA-N

物化性质

• 熔点：
  57-58 °C(Solv: hexane (110-54-3))
• 沸点：
  138-150 °C(Press: 2 Torr)
• 密度：
  1.179±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4-(chloromethyl)-s-hydrindacene 生成 (s-4-hydrindacen-4-yl)acetonitrile
  参考文献：
  名称：

  VEJDELEK, Z.;PROTIVA, M.;BARTOSOVA, M.

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3,6,7-四氢-S-茚满-1(5H)-酮 在 盐酸 、 氢氧化钾 、 氯化亚砜 、 一水合肼 作用下， 反应 2.0h， 生成 4-(chloromethyl)-s-hydrindacene
  参考文献：
  名称：

  4-(Aminomethyl)-s-hydrindacenes and 4,8-bis(aminomethyl)-s-hydrindacenes; Synthesis and pharmacological screening

  摘要：

  DOI：

  10.1135/cccc19773094

文献信息

• 3-(s-Hydrindacen-4-yl)propylamines and 4-(s-hydrindacen-4-yl)butylamines; Synthesis and pharmacological screening
  作者：Zdeněk Vejdělek、Marie Bartošová、Miroslav Protiva

  DOI：10.1135/cccc19811800

  日期：——

  4-Chloromethyl-s-hydrindacene (VIIa) was transformed via the malonic acid derivatives VIIIa and IXa to the acid Xb which afforded in four steps the homological acid Xc. Reactions of chlorides of both acids (XIbc ) with dimethylamine, 1-methylpiperazine and 1-(2-hydroxyethyl)piperazine led to the amides XIIbc-XIVbc which were reduced with lithium aluminium hydride to the title compounds IVcd-VIcd. The amines obtained show central neuroleptic effects only in subtoxic doses; they are also potent local anaesthetics and have significant spasmolytic activity of the neurotropic as well as musculotropic type.

  4-氯甲基-s-氢吲哚烯（VIIa）经由丙二酸衍生物VIIIa和IXa转化为酸Xb，经过四步得到同系酸Xc。两种酸（XIbc）的氯化物与二甲胺、1-甲基哌嗪和1-(2-羟乙基)哌嗪的反应形成酰胺XIIbc-XIVbc，然后用氢化铝锂还原为IVcd-VIcd标题化合物。所得胺仅在次毒性剂量下表现出中枢神经阻滞作用；它们也是有效的局部麻醉剂，并具有神经型和肌肉型的显著解痉活性。
• Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics
  作者：Anton Stuetz、Apostolos Georgopoulos、Waltraud Granitzer、Gabor Petranyi、Daniel Berney

  DOI：10.1021/jm00151a019

  日期：1986.1

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.
• Kmonicek, Vojtech; Vejdelek, Zdenek; Protiva, Miroslav, Collection of Czechoslovak Chemical Communications, 1990, vol. 55, # 6, p. 1602 - 1612
  作者：Kmonicek, Vojtech、Vejdelek, Zdenek、Protiva, Miroslav

  DOI：——

  日期：——
• 2-(s-Hydrindacen-4-yl)ethylamines and their 1-methyl and 1,1-dimethyl derivatives; Synthesis and pharmacological screening
  作者：Zdeněk J. Vejdělek、Marie Bartošová、Miroslav Ryska、Miroslav Protiva

  DOI：10.1135/cccc19781732

  日期：——
• KMONICEK, VOJTECH;VEJDELEK, ZDENEK;PROTIVA, MIROSLAV, COLLECT. CZECHOSL. CHEM. COMMUN., 55,(1990) N, C. 1602-1612
  作者：KMONICEK, VOJTECH、VEJDELEK, ZDENEK、PROTIVA, MIROSLAV

  DOI：——

  日期：——