4,6-diiodo-N-(naphthalen-2-ylmethyl)pyrimidin-5-amine | 1026374-24-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4,6-diiodo-N-(naphthalen-2-ylmethyl)pyrimidin-5-amine
• CAS: 1026374-24-2
• 化学式: C₁₅H₁₁I₂N₃
• 分子量: 487.081
• InChiKey: WROPXYKCRDPVOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,6-diiodo-N-(naphthalen-2-ylmethyl)pyrimidin-5-amine 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 氨 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 乙腈 为溶剂， 反应 14.0h， 生成 5-N-methyl-6-[2-(6-morpholin-4-ylpyridin-3-yl)ethynyl]-5-N-(naphthalen-2-ylmethyl)pyrimidine-4,5-diamine
  参考文献：
  名称：

  Design, Synthesis, and Structure−Activity Relationship of 6-Alkynylpyrimidines as Potent Adenosine Kinase Inhibitors

  摘要：

  Adenosine (ADO) is an extracellular signaling molecule within the central and peripheral nervous system. Its concentration is increased at sites of tissue injury and inflammation. One of the mechanisms by which antinociceptive and antiinflammatory effects of ADO can be enhanced consists of inhibition of adenosine kinase (AK), the primary metabolic enzyme for ADO. Novel nonnucleoside AK inhibitors based on 4-amino-6-alkynylpyrimidines were prepared, and the importance of the length of the linker at the 5-position for high affinity AK inhibition was demonstrated. Compounds with 2- and 3-atom linkers were the most potent AK inhibitors. Optimization of their physicochemical properties led to 31a and 37a that effectively reduced pain and inflammation in animal models.

  DOI：

  10.1021/jm020049a
• 作为产物：
  描述：

  2-溴甲基萘 、 4,6-二碘-5-氨基嘧啶 在 sodium hydride 、 四丁基碘化铵 作用下， 以 四氢呋喃 为溶剂， 生成 4,6-diiodo-N-(naphthalen-2-ylmethyl)pyrimidin-5-amine
  参考文献：
  名称：

  Design, Synthesis, and Structure−Activity Relationship of 6-Alkynylpyrimidines as Potent Adenosine Kinase Inhibitors

  摘要：

  Adenosine (ADO) is an extracellular signaling molecule within the central and peripheral nervous system. Its concentration is increased at sites of tissue injury and inflammation. One of the mechanisms by which antinociceptive and antiinflammatory effects of ADO can be enhanced consists of inhibition of adenosine kinase (AK), the primary metabolic enzyme for ADO. Novel nonnucleoside AK inhibitors based on 4-amino-6-alkynylpyrimidines were prepared, and the importance of the length of the linker at the 5-position for high affinity AK inhibition was demonstrated. Compounds with 2- and 3-atom linkers were the most potent AK inhibitors. Optimization of their physicochemical properties led to 31a and 37a that effectively reduced pain and inflammation in animal models.

  DOI：

  10.1021/jm020049a