(S)-5′-(tert-butyldimethylsilyloxy)-4′-(3,6-dihydro-2H-pyran-4-yl)-2′-(tetrahydro-2H-pyran-4-yl)-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carbaldehyde | 1332486-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (S)-5′-(tert-butyldimethylsilyloxy)-4′-(3,6-dihydro-2H-pyran-4-yl)-2′-(tetrahydro-2H-pyran-4-yl)-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carbaldehyde
• 英文别名: (S)-5'-(tert-butyldimethylsilyloxy)-4'-(3,6-dihydro-2H-pyran-4-yl)-2'-(tetrahydro-2H-pyran-4-yl)-6',8'-dihydro-5'H-spiro[cyclobutane-1,7'-quinoline]-3'-carbaldehyde；(5S)-5-[tert-butyl(dimethyl)silyl]oxy-4-(3,6-dihydro-2H-pyran-4-yl)-2-(oxan-4-yl)spiro[6,8-dihydro-5H-quinoline-7,1'-cyclobutane]-3-carbaldehyde
• CAS: 1332486-98-2
• 化学式: C₂₉H₄₃NO₄Si
• 分子量: 497.75
• InChiKey: JWBNCWLFCBFNJD-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.77
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  57.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-5′-(tert-butyldimethylsilyloxy)-4′-(3,6-dihydro-2H-pyran-4-yl)-2′-(tetrahydro-2H-pyran-4-yl)-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3′-carbaldehyde 、 2-溴-5-(三氟甲基)吡啶 生成 (R)-((S)-5′-(tert-butyldimethylsilyloxy)-4′-(3,6-dihydro-2H-pyran-4-yl)-2′-(tetrahydro-2H-pyran-4-yl)-6′,8′-dihydro-5′H-spiro[cyclobutane-1,7′-quinoline]-3-yl)(5-(trifluoromethyl)pyridin-2-yl)methanol
  参考文献：
  名称：

  Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation

  摘要：

  本发明涉及公式I所定义的化合物，其中变量R1-R8如描述中所定义，具有有价值的药理活性。特别地，这些化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适用于治疗和预防可以受到该酶抑制影响的疾病。

  公开号：

  US20130053404A1

文献信息

• TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION
  申请人：WAGNER Holger

  公开号：US20120046304A1

  公开（公告）日：2012-02-23

  The present invention relates to compounds defined by formula I wherein the variables R 1 -R 8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.

  本发明涉及公式I定义的化合物，其中变量R1-R8如描述中所定义，具有有价值的药理活性。特别地，这些化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适用于治疗和预防可以受到该酶抑制影响的疾病。