3β-benzoyloxy-24-methylenecholest-5-ene | 95677-39-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-benzoyloxy-24-methylenecholest-5-ene
• 英文别名: O-Benzoyl-ostreasterol
• CAS: 95677-39-7
• 化学式: C₃₅H₅₀O₂
• 分子量: 502.781
• InChiKey: MLUXRSPFYMPYBM-WASXNZKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.42
• 重原子数：
  37.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3β-benzoyloxy-24-methylenecholest-5-ene 在 吡啶 、 氢氧化钾 、 四氧化锇 、 硫化氢 作用下， 以 吡啶 、 甲醇 、 四氯化碳 、 乙醚 为溶剂， 反应 46.5h， 生成 (24R)-stigmast-5-ene-3β,24-diol
  参考文献：
  名称：

  （24 R）-和（24 S）-24,28-环氧麦角-5-en-3β-ols的合成。黄粉虫昆虫中代谢的底物立体特异性

  摘要：

  合成了（24 R）-和（24 S）-24,28-环氧麦角-5-en-3β-ol，并指定了其在C-24的构型。当将这24,28-环氧化合物标记为labeled并在单独的实验中喂入黄粉虫幼虫时，只有（24 R）立体异构体有效地转化为胆固醇，表明该植物甾醇代谢的步骤中该昆虫表现出高度的底物立体特异性。

  DOI：

  10.1039/p19840002039
• 作为产物：
  描述：

  苯甲酰氯 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 作用下， 生成 3β-benzoyloxy-24-methylenecholest-5-ene
  参考文献：
  名称：

  Roadside Particulate Air Pollution in Bangkok

  摘要：

  Airborne fine particles of PM2.5-10 and PM2.5 in Bangkok, Nonthaburi, and Ayutthaya were measured from December 22, 1998, to March 26, 1999, and from November 30, 1999, to December 2, 1999. Almost all the PM10 values in the high-polluted (H) area exceeded the Thailand National Ambient Air Quality Standards (NAAQS) of 120 mug/m(3). The low-polluted (L) area showed low PM10 (34-74 mug/m(3) in the daytime and 54-89 mug/m(3) at night). PM2.5 in the H area varied between 82 and 143 mug/m(3) in the daytime and between 45 and 146 mug/m(3) at night. In the L area, PM2.5 was quite low both day and night and varied between 24 and 54 mug/m(3), lower than the U.S. Environmental Protection Agency (EPA) standard (65 mug/m(3)). The personal exposure results showed a significantly higher proportion of PM2.5 to PM10 in the H area than in the L area (H = 0.80 +/- 0.08 and L = 0.65 +/- 0.04).Roadside PM10 was measured simultaneously with the Thailand Pollution Control Department (PCD) monitoring station at the same site and at the intersections where police work. The result from dual simultaneous measurements of PM10 showed a good correlation (correlation coefficient: r = 0.93); however, PM levels near the roadside at the intersections were higher than the concentrations at the monitoring station. The relationship between ambient PM level and actual personal exposures was examined. Correlation coefficients between the general ambient outdoors and personal exposure levels were 0.92 for both PM2.5 and PM10.Bangkok air quality data for 1997-2000, including 24-hr average PM10, NO2, SO2, and O-3 from eight PCD monitoring stations, were analyzed and validated. The annual arithmetic mean PM10 of the PCD data at the roadside monitoring stations for the last 3 years decreased from 130 to 73 mug/m(3), whereas the corresponding levels at the general monitoring stations decreased from 90 to 49 mug/m(3). The proportion of days when the level of the 24-hr average PM10 exceeded the NAAQS was between 13 and 26% at roadside stations. PCD data showed PM10 was well correlated with NO2 but not with SO2, suggesting that automobile exhaust is the main source of the particulate air pollution. The results obtained from the simultaneous measurement of PM2.5 and PM10 indicate the potential environmental health hazard of fine particles. In conclusion, Bangkok traffic police were exposed to high levels of automobile-derived particulate air pollution.

  DOI：

  10.1080/10473289.2002.10470845

文献信息

• Bergmann; Dusza, Justus Liebigs Annalen der Chemie, 1957, vol. 603, p. 36,41
  作者：Bergmann、Dusza

  DOI：——

  日期：——
• Bergmann, Journal of Biological Chemistry, 1934, vol. 104, p. 317,324
  作者：Bergmann

  DOI：——

  日期：——