4-(2-甲基丙基氨基)苯酚 | 104-17-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-(2-甲基丙基氨基)苯酚
• 英文名称: 4-Isobutylamino-phenol
• 英文别名: 4-(Isobutylamino)phenol；4-(2-methylpropylamino)phenol
• CAS: 104-17-6
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: PAGULGKYMQWKBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(2-甲基丙基氨基)苯酚 、 氯甲酰乙酸乙酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到ethyl 3-((4-hydroxyphenyl)(isobutyl)amino)-3-oxopropanoate
  参考文献：
  名称：

  Oxidative Carbon−Carbon Bond Formation in the Synthesis of Bioactive Spiro β-Lactams

  摘要：

  New oxidative dearomatization procedures leading to Spiro beta-lactams and oxindoles were developed. By a variation of the oxidative reaction conditions, the usefulness of phenolic amides, derived from 4-aminophenol, in the synthesis of structurally different types of molecules was demonstrated.

  DOI：

  10.1021/ol901005x
• 作为产物：
  描述：

  isobutyraldehyde-(4-hydroxy-phenylimine) 在 乙醇 、 铂 作用下， 生成 4-(2-甲基丙基氨基)苯酚
  参考文献：
  名称：

  US2270215

  摘要：

  公开号：

文献信息

• Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
  申请人：Beutel A. Bruce

  公开号：US20060178400A1

  公开（公告）日：2006-08-10

  The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

  本发明涉及式(I)的化合物，它们抑制乙酰辅酶A羧化酶（ACC），并且对于预防或治疗人类的代谢综合征、2型糖尿病、肥胖、动脉粥样硬化和心血管疾病是有用的。
• [EN] INHIBITORS OF ACETYL-COA CARBOXYLASE<br/>[FR] INHIBITEURS DE L'ACÉTYL-COA CARBOXYLASE
  申请人：FOREST LAB HOLDINGS LTD

  公开号：WO2010127208A1

  公开（公告）日：2010-11-04

  The present invention relates to compounds that act as acetyl-CoA carboxylase (ACC) inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

  本发明涉及作为乙酰辅酶A羧化酶（ACC）抑制剂的化合物。该发明还涉及制备这些化合物的方法、含有这些化合物的组合物，以及使用这些化合物进行治疗的方法。
• Process for preparing N-alkyl-substituted aminophenols
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0411817A2

  公开（公告）日：1991-02-06

  A process for preparing an N-alkyl-substituted amino­phenol comprises continuously feeding an aldehyde or a ketone to a reaction system containing an organic solvent, e.g., methanol or ethanol, a catalyst for reduction (e.g., Pt or Pd), hydrogen, and an aminophenol to conduct a reductive alkylation reaction, wherein said reductive alkylation react­ion is carried our while continuously adding an organic carboxylic acid (e.g. a mono or di-carboxylic or hydroxy­carboxylic acid of up to 8 carbon atoms), in amount of 0.05 to 5 wt % of the aminophenol, diluted with said solvent. The aldehyde or ketone can first be added to the system apart from the acid, which is added continuously when hydrogen absorption has begun. The process attains a high yield even when the catalyst is repeatedly reused, and does not cause corrosion of equipment.

  一种制备 N-烷基取代氨基苯酚的工艺包括：向含有有机溶剂（如甲醇或乙醇）、还原催化剂（如铂或钯）、氢和氨基苯酚的反应体系中连续加入醛或酮，以进行还原烷基化反应、其中，在进行还原烷基化反应的同时，不断加入用所述溶剂稀释的有机羧酸（例如，碳原子数不超过 8 的单羧酸或二羧酸或羟基羧酸），其用量为氨基苯酚的 0.05 至 5 wt %。醛或酮可以先与酸分开加入体系中，当开始吸氢时再继续加入。 即使催化剂重复使用，该工艺也能达到很高的产量，而且不会对设备造成腐蚀。
• Production of aminophenols
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP0831081A1

  公开（公告）日：1998-03-25

  A method of producing N,N-disubstituted aminophenols of the general formula wherein R1 and R2 are the same or different and each represents a saturated or unsaturated aliphatic hydrocarbyl, cycloalkyl, aralkyl, the phenyl ring of which may be further substituted, alkoxyalkyl, or a cycloalkylalkyl, except that R1 and R2 are not simultaneously methyl and R' represents hydrogen, halogen, nitro, cyano, alkyl or alkoxy, which comprises reacting an aminophenol of general formula wherein R3 represents hydrogen or R1, and R' is as defined above, with an organic halide species of general formula R2X wherein R2 is as defined above and X is halogen under aqueous acidic conditions with the periodic addition of an acid trapping agent in such a way that continuous monitoring of pH is not required.

  一种生产通式为 N,N-二取代氨基苯酚的方法 其中 R1 和 R2 相同或不同，各自代表饱和或不饱和脂肪族烃基、环烷基、芳烷基、 其中 R1 和 R2 不同时为甲基，R'代表氢、卤素、硝基、氰基、烷基或烷氧基。 其中 R3 代表氢或 R1，R'如上定义，与通式 R2X 的有机卤化物（其中 R2 如上定义，X 为卤素）在酸性水溶液条件下反应，并定期添加酸捕捉剂，从而无需持续监测 pH 值。
• Preparation of p-(nu-primary aliphatic amino) phenols
  申请人：DU PONT

  公开号：US02249352A1

  公开（公告）日：1941-07-15