3-chloro-8-nitro-2-piperidin-1-yl-1,4-naphthoquinone | 57612-29-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-chloro-8-nitro-2-piperidin-1-yl-1,4-naphthoquinone
• 英文别名: 5-Nitro-3-piperidino-2-chlor-1,4-naphthochinon；2-chloro-5-nitro-3-piperidin-1-yl-[1,4]naphthoquinone；2-chloro-5-nitro-3-piperidin-1-ylnaphthalene-1,4-dione
• CAS: 57612-29-0
• 化学式: C₁₅H₁₃ClN₂O₄
• 分子量: 320.732
• InChiKey: DMIMWBGRBJBSDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.91
• 重原子数：
  22.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  80.52
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2,3-二氯-5-硝基-1,4-萘醌 、 哌啶 生成 3-chloro-8-nitro-2-piperidin-1-yl-1,4-naphthoquinone
  参考文献：
  名称：

  FOKIN E. P.; DETSINA A. M., IZV. SIB. OTD. AN CCCP, 1975, HO 12, CEP. XIM. N. , VYP. 5, 81-8+

  摘要：

  DOI：

文献信息

• Solid-phase synthesis of 2-amino-3-chloro-5- and 8-nitro-1,4-naphthoquinones: a new and general colorimetric test for resin-bound amines
  作者：Christopher Blackburn

  DOI：10.1016/j.tetlet.2005.01.049

  日期：2005.2

  Treatment of resin-bound primary or secondary alkyl and arylamines with 2,3-dichloro-5-nitro-1,4-naphthoquinone leads to the rapid formation of intensely colored (red) beads. The resulting 2-amino-3-chloro-5- and 8-nitro-1,4-naphthoquinones can be cleaved rapidly from acid-labile supports in high yields and purities. The reaction is of value as a sensitive and general qualitative test for amino groups on-resin that can be followed by cleavage for characterization and quantification of the chromogen(s) responsible for the color. (C) 2005 Elsevier Ltd. All rights reserved.