Org OD 02-0 | 13258-85-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Org OD 02-0
• 英文别名: 10-Vinyl-19-norpregn-4-ene-3,20-dione；(8S,9S,10S,13S,14S,17S)-17-acetyl-10-ethenyl-13-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 13258-85-0
• 化学式: C₂₂H₃₀O₂
• 分子量: 326.479
• InChiKey: VFNRBPBEOXXVPX-GCOBIYGJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Compositions and methods for decreasing, or preventing or reversing gain of, skin pigmentation in a mammalian subject
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US11236074B2

  公开（公告）日：2022-02-01

  The present invention includes compounds, compositions comprising the same, and methods using the compounds and/or compositions therein, for modulating skin pigmentation in a mammalian subject. In certain embodiments, the compounds of the invention treat or prevent skin disorders or diseases associated with hyperpigmentation in the subject. In other embodiments, the compounds of the invention act as antagonist to the non-canonical sex steroid hormone receptor GPRE1 and do not bind to a canonical nuclear estrogen receptor (ER). In yet other embodiments, the compounds of the invention comprise acts as agonists to the non-canonical sex steroid hormone receptor PAQR7 and do not bind to a canonical nuclear progesterone receptor (PR).

  本发明包括用于调节哺乳动物皮肤色素沉着的化合物、包含这些化合物的组合物以及使用这些化合物和/或组合物的方法。在某些实施方案中，本发明的化合物可治疗或预防与受试者色素沉着相关的皮肤失调或疾病。在其他实施方案中，本发明化合物作为非典型性类固醇激素受体 GPRE1 的拮抗剂，不与典型核雌激素受体（ER）结合。在另一些实施方案中，本发明的化合物包括作为非典型性类固醇激素受体 PAQR7 的激动剂，并且不与典型的核黄体酮受体（PR）结合。
• COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT
  申请人：The Trustees of The University of Pennsylvania

  公开号：EP3280410A2

  公开（公告）日：2018-02-14
• [EN] COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR DIMINUTION OU PRÉVENTION OU INVERSION DU GAIN DE LA PIGMENTATION DE LA PEAU CHEZ UN SUJET MAMMIFÈRE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2016164460A2

  公开（公告）日：2016-10-13

  The present invention includes compounds, compositions comprising the same, and methods using the compounds and/or compositions therein, for modulating skin pigmentation in a mammalian subject. In certain embodiments, the compounds of the invention treat or prevent skin disorders or diseases associated with hyperpigmentation in the subject. In other embodiments, the compounds of the invention act as antagonist to the non-canonical sex steroid hormone receptor GPRE1 and do not bind to a canonical nuclear estrogen receptor (ER). In yet other embodiments, the compounds of the invention comprise acts as agonists to the non-canonical sex steroid hormone receptor PAQR7 and do not bind to a canonical nuclear progesterone receptor (PR).