1-Diphenylphosphoryl-1,2,3,4-tetrahydronaphthalene | 1418093-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-Diphenylphosphoryl-1,2,3,4-tetrahydronaphthalene
• 英文别名: 1-diphenylphosphoryl-1,2,3,4-tetrahydronaphthalene
• CAS: 1418093-14-7
• 化学式: C₂₂H₂₁OP
• 分子量: 332.382
• InChiKey: CDIDBAVIOZVYIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,4-二氢-1(2H)-萘酮 在 copper(l) iodide 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 3.5h， 生成 1-Diphenylphosphoryl-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Reductive coupling reactions: a new strategy for C(sp3)–P bond formation

  摘要：

  The C(sp(3))-P bond forming reaction utilizing N-tosylhydrazones as readily available alkylating reagents was developed, which provides a new opportunity for preparing phosphine oxide derivatives with moderate to good yields. This reductive coupling reaction is proposed to proceed through an insertion of copper carbene into P-H bond of H-phosphorus oxides. The salient features of the reaction are operational simplicity and functional-group tolerance. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.064

文献信息

• Reductive coupling reactions: a new strategy for C(sp3)–P bond formation
  作者：Zi-Sheng Chen、Zhao-Zhao Zhou、Hui-Liang Hua、Xin-Hua Duan、Jian-Yi Luo、Jia Wang、Ping-Xin Zhou、Yong-Min Liang

  DOI：10.1016/j.tet.2012.11.064

  日期：2013.1

  The C(sp(3))-P bond forming reaction utilizing N-tosylhydrazones as readily available alkylating reagents was developed, which provides a new opportunity for preparing phosphine oxide derivatives with moderate to good yields. This reductive coupling reaction is proposed to proceed through an insertion of copper carbene into P-H bond of H-phosphorus oxides. The salient features of the reaction are operational simplicity and functional-group tolerance. (C) 2012 Elsevier Ltd. All rights reserved.