多柔比星杂质6 | 69429-21-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 中文名称: 多柔比星杂质6
• 英文名称: doxorubicin
• 英文别名: (2S,4S)-4-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-2-carboxylic acid；(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxylic acid
• CAS: 69429-21-6
• 化学式: C₂₆H₂₇NO₁₁
• 分子量: 529.5
• InChiKey: UOZJSBYGENSCDJ-FHRHSTJFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  206
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  阿霉素 在 sodium periodate 作用下， 以 甲醇 、 水 为溶剂， 生成 多柔比星杂质6
  参考文献：
  名称：

  [EN] ANTHRACYCLINE ANTIBODY CONJUGATES
  [FR] CONJUGUÉS D'ANTICORPS D'ANTHRACYCLINE

  摘要：

  The present disclosure provides,inter alia, antibody drug conjugates that are useful in treating various diseases such as cancer.

  公开号：

  WO2022251850A1

文献信息

• Compounds and pharmaceutical compositions for the treatment of liver disorders
  申请人：Sommadossi Jean-Pierre

  公开号：US20080261913A1

  公开（公告）日：2008-10-23

  Provided herein are compounds, compositions and methods for the treatment of liver disorders, including liver cancer and metabolic diseases, such as diabetes, hyperlipidemia, atherosclerosis, and obesity. Specifically, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.