4-(2-羟基乙基)哌嗪-1-乙烷磺酸钾 | 82207-62-3

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 4-(2-羟基乙基)哌嗪-1-乙烷磺酸钾
• 中文别名: N-(2-羟乙基)哌嗪-N'-(2-乙磺酸)钾盐；N-(2-羟乙基)哌嗪-N′-(2-乙磺酸)钾盐
• 英文名称: Potassium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate
• 英文别名: potassium;2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate
• CAS: 82207-62-3
• 化学式: C8H17KN2O4S
• 分子量: 276.4
• InChiKey: KWURIFKZTJGMFD-UHFFFAOYSA-M

物化性质

• 溶解度：
  H2O：50 mg/mL，澄清，无色

计算性质

• 辛醇/水分配系数(LogP)：
  -4.85
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  92.3
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 安全说明：
  S22,S24/25

文献信息

• Dihydropyrancarboxamides and uses thereof
  申请人：——

  公开号：US20040059138A1

  公开（公告）日：2004-03-25

  The present invention provides novel dihydropyrancarboxamide compounds of formula (I): 1 and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 -R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.

  本发明提供了式（I）的新颖二氢吡喃羧酰胺化合物： 1 以及这些化合物的集合，并提供了合成这些化合物的方法；其中R 1 -R 6 如本文所定义。此外，本发明提供了用于治疗增殖性疾病和癌症等疾病的药物组合物和方法。
• Bicyclic Dihydropyrimidines and Uses Thereof
  申请人：Mazitschek Ralph

  公开号：US20100152206A1

  公开（公告）日：2010-06-17

  The present invention provides compounds having formula (I): (I) and pharmaceutically acceptable derivatives thereof; as described generally and in subclasses herein, which compounds are useful as kinesin inhibitors (e.g., Eg5 inhibitors), and thus are useful, for example, for the treatment of proliferative disorders e.g., cancer. The invention additionally provides methods for preparing compounds of the invention, compositions comprising them, and methods for the use thereof in the treatment of various disorders where Eg5 is involved. In certain embodiments, the present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle. One class of proteins which acts on the mitotic spindle is the family of mitotic kinesins, a subset of the kinesin superfamily.

  本发明提供具有以下式（I）的化合物：（I）及其药学上可接受的衍生物；如本文档中一般描述和在子类中描述，这些化合物可用作kinesin抑制剂（例如，Eg5抑制剂），因此可用于治疗增殖性疾病，例如癌症。本发明还提供制备本发明化合物的方法，包含它们的组合物，以及在治疗涉及Eg5的各种疾病中使用它们的方法。在某些实施例中，本发明提供用于抑制细胞生长的化合物、组合物、方法和系统。更具体地，本发明提供了一种能够抑制代谢活跃细胞中有丝分裂的方法、化合物和组合物。本发明的化合物、组合物和方法抑制了参与有丝分裂纺锤体的组装和维护的蛋白质的活性。作用于有丝分裂纺锤体的蛋白质家族之一是有丝分裂kinesin家族，是kinesin超家族的一个子集。
• Kinesin inhibitors
  申请人：Feng Yan

  公开号：US20050004156A1

  公开（公告）日：2005-01-06

  The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions which are capable of inhibiting mitosis in metabolically active cells. Compounds, compositions and methods of the present invention inhibit the activity of a protein involved in the assembly and maintenance of the mitotic spindle. One class of proteins which acts on the mitotic spindle is the family of mitotic kinesins, a subset of the kinesin superfamily.

  本发明提供了用于抑制细胞生长的化合物、组合物、方法和系统。更具体地，本发明提供了一种能够抑制代谢活跃细胞中有丝分裂的方法、化合物和组合物。本发明的化合物、组合物和方法抑制了参与有丝分裂纺锤体组装和维持的蛋白质的活性。作用于有丝分裂纺锤体的蛋白质类别之一是有丝分裂动力蛋白家族中的一类蛋白质，这是有丝分裂动力蛋白超家族的一个子集。
• CELL PERMEABLE INHIBITORS OF ANAPHASE PROMOTING COMPLEX
  申请人：President and Fellows of Harvard College

  公开号：US20150328214A1

  公开（公告）日：2015-11-19

  The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism.

  本公开提供了用于治疗细胞周期紊乱的组合物和方法。本公开的组合物包括proTAME和apcin，它们的组合通过协同作用机制抑制负责有丝分裂后期促进复合物（APC）的活性或功能。其中，proTAME是TAME的前药类似物。
• BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS
  申请人：INVISTA TECHNOLOGIES S.a.r.l.

  公开号：US20150337275A1

  公开（公告）日：2015-11-26

  Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.

  本发明实施例涉及在分离酶存在或在表达这些酶的重组宿主细胞存在下，生物合成双或三功能C7烷的方法。这些双或三功能C7烷在生产尼龙-7、尼龙-7，x、尼龙-x，7和聚酯中作为中间体是有用的。