4-(3-phenylaminopropyl)piperidine | 359878-70-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(3-phenylaminopropyl)piperidine
• 英文别名: N-(3-piperidin-4-ylpropyl)aniline
• CAS: 359878-70-9
• 化学式: C₁₄H₂₂N₂
• 分子量: 218.342
• InChiKey: UERLPVUQLRIZGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基-4-哌啶酮 、 3-苯基-1-丙胺 生成 4-(3-phenylaminopropyl)piperidine
  参考文献：
  名称：

  Azacyclic compounds

  摘要：

  提供了用于治疗疾病的化合物和方法，其中修改5-羟色胺受体活性具有有益效果。在该方法中，给需要此类治疗的患者施用足够的化合物。

  公开号：

  US20020004513A1

文献信息

• AZACYCLIC COMPOUNDS
  申请人：ACADIA Pharmaceuticals Inc.

  公开号：US20150259291A1

  公开（公告）日：2015-09-17

  Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment.

  提供用于治疗修改血清素能受体活性具有有益效果的疾病状态的化合物和方法。在方法中，将有效量的化合物施用于需要此类治疗的病人。
• [EN] AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES<br/>[FR] COMPOSES AZACYCLIQUES UTILISES DANS LE TRAITEMENT DE MALADIES LIEES A LA SEROTONINE
  申请人：ACADIA PHARM INC

  公开号：WO2001066521A1

  公开（公告）日：2001-09-13

  Compound and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound of formula (II) is administered to a patient in need of such treatment.

  提供了一种化合物和方法，用于治疗疾病状态，其中修饰5-羟色胺受体活性具有益处。在该方法中，将II式化合物的有效量用于需要此类治疗的患者。
• Method of improving the compatibility of a fuel additive composition containing a mannich condensation product
  申请人：——

  公开号：US20040000089A1

  公开（公告）日：2004-01-01

  A method of improving the compatibility of a fuel additive composition comprising blending together the following components: a) a Mannich condensation product of (1) a high molecular weight alkyl-substituted hydroxyaromatic compound, (2) an amine having the formula: 1 wherein A is CH or nitrogen, R 1 , R 2 , R 3 are independently hydrogen or lower alkyl of 1 to about 6 carbon atoms and each R 2 and R 3 is independently selected in each —CR 2 R 3 — unit, and x is an integer from 1 to about 6; and (3) an aldehyde, wherein the respective molar ratio of reactants (1), (2), and (3) is 1:0.1-2:0.1-2; b) a hydrocarbyl-terminated poly(oxyalkylene) monool; c) a carboxylic acid as represented by the formula: R 4 (COOH) y wherein R 4 represents a hydrocarbyl group having about 2 to about 50 carbon atoms, and y represents an integer of 1 to about 4; and d) an anhydride selected from the group consisting of succinic, glutaric, phthalic, and alkyl anhydrides.

  一种改善燃料添加剂组合物的相容性的方法，包括混合以下组分：a）高分子量烷基取代的羟基芳香化合物的Mannich缩合物，其中该芳香化合物与1个具有以下公式的胺反应：1其中A是CH或氮，R1、R2、R3分别独立地表示氢或1到约6个碳原子的低级烷基，每个R2和R3在每个—CR2R3—单元中独立选择，x是1到约6的整数；以及1个醛，其中反应物（1）、（2）和（3）的各自摩尔比为1:0.1-2:0.1-2；b）烃基终止的聚（氧烷基）单醇；c）由以下公式表示的羧酸：R4（COOH）y其中R4表示具有约2到约50个碳原子的烃基，y表示1到约4的整数；以及d）从琥珀酸、戊二酸、邻苯二甲酸和烷基酸酐组成的羧酸酐。
• USE OF 4-AMINO-PIPERIDINES FOR TREATING SLEEP DISORDERS
  申请人：van Kammen Daniel

  公开号：US20080051429A1

  公开（公告）日：2008-02-28

  Inverse agonists and antagonists of serotonin receptors are disclosed for use in treating sleep disorders such as insomnia, and specifically sleep maintenance insomnia. The compound increase slow wave sleep, decrease the number of awakenings after sleep onset, and decrease the time awake after sleep onset.

  揭示了逆向激动剂和拮抗剂的血清素受体，用于治疗睡眠障碍，如失眠，特别是睡眠维持失眠。该化合物增加慢波睡眠，减少入睡后醒来的次数，减少入睡后清醒的时间。
• METHODS OF TREATMENT USING SELECTIVE 5-HT2A INVERSE AGONISTS
  申请人：ANDERSSON Carl-Magnus A.

  公开号：US20110301191A1

  公开（公告）日：2011-12-08

  Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is administered to a patient in need of such treatment.

  本发明提供了用于治疗疾病状态的化合物和方法，其中修改5-羟色胺受体活性具有益处。在该方法中，向需要此类治疗的患者施用有效量的化合物。