7-Chloro-1'-methylspiro[1,3-dihydroquinazoline-2,4'-piperidine]-4-one | 1531637-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-Chloro-1'-methylspiro[1,3-dihydroquinazoline-2,4'-piperidine]-4-one
• 英文别名: 7-chloro-1'-methylspiro[1,3-dihydroquinazoline-2,4'-piperidine]-4-one
• CAS: 1531637-12-3
• 化学式: C₁₃H₁₆ClN₃O
• 分子量: 265.743
• InChiKey: BIWRZKPGCFGJPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-甲基-4-哌啶酮 、 2-氨基-4-氯苯腈 在 SrCl₂ modified silica sulfuric acid 作用下， 以 水 为溶剂， 反应 3.0h， 以74%的产率得到7-Chloro-1'-methylspiro[1,3-dihydroquinazoline-2,4'-piperidine]-4-one
  参考文献：
  名称：

  Metal modified SSA as a heterogeneous catalyst to promote the cyclocondesation of o-aminobenzonitriles with cycloketones in water

  摘要：

  A novel solid catalyst based on silica sulfuric acid (SSA) was prepared. When SSA was treated with Lewis acids, metal ions can be easily immobilized on silica surface, which results in strengthening Lewis acidity. The novel solid catalyst was demonstrated to be efficient in promoting the cyclocondesation of o-aminobenzonitriles with cycloketones in water, and hence promising in the application of pharmaceutical study and production. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.12.001

文献信息

• Metal modified SSA as a heterogeneous catalyst to promote the cyclocondesation of o-aminobenzonitriles with cycloketones in water
  作者：Li Jun Zhang、Jian Ling Yu、Wei Li Wang、Heng Li、Dan Dan Xu、Ya Dong Bi、Fu De Liu

  DOI：10.1016/j.tetlet.2013.12.001

  日期：2014.1

  A novel solid catalyst based on silica sulfuric acid (SSA) was prepared. When SSA was treated with Lewis acids, metal ions can be easily immobilized on silica surface, which results in strengthening Lewis acidity. The novel solid catalyst was demonstrated to be efficient in promoting the cyclocondesation of o-aminobenzonitriles with cycloketones in water, and hence promising in the application of pharmaceutical study and production. (C) 2013 Elsevier Ltd. All rights reserved.