1-Cyclopropyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-5,8-dimethyl-1H-quinazoline-2,4-dione | 479088-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-Cyclopropyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-5,8-dimethyl-1H-quinazoline-2,4-dione
• 英文别名: 1-Cyclopropyl-6-fluoro-7-[3-fluoro-4-(3,3,3-trifluoro-1,2-dihydroxy-2-trifluoromethylpropyl)pyrrolidin-1-yl]-5,8-dimethyl-1H-quinazolinedione；1-Cyclopropyl-6-fluoro-7-[3-fluoro-4-[3,3,3-trifluoro-1,2-dihydroxy-2-(trifluoromethyl)propyl]pyrrolidin-1-yl]-5,8-dimethylquinazoline-2,4-dione
• CAS: 479088-65-8
• 化学式: C₂₁H₂₁F₈N₃O₄
• 分子量: 531.403
• InChiKey: LQRLPSWGMOUACK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  93.1
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• Antibacterial agents
  申请人：——

  公开号：US20030114666A1

  公开（公告）日：2003-06-19

  The present invention provides compounds of formula (I): 1 wherein R 1 -R 6 and J and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.

  本发明提供了化合物(I)的公式：1其中R1-R6和J和K具有规范中定义的任何值，以及其药学上可接受的盐，可用作抗菌剂。还揭示了包含一个或多个公式I化合物的制药组合物，制备公式I化合物的过程以及制备公式I化合物有用的中间体。
• QUINAZOLINEDIONES AS ANTIBACTERIAL AGENTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1401830A2

  公开（公告）日：2004-03-31
• [EN] ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTERIENS
  申请人：WARNER LAMBERT CO

  公开号：WO2002102793A2

  公开（公告）日：2002-12-27

  The present invention provides compounds of formula (I): wherein R1-R6 and J and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of formula I, processes for preparing compounds of formula I, and intermediates useful for preparing compounds of formula I.