N-[2-(2-methoxyphenyl)-3-oxo-1H-isoindol-4-yl]-2-pyridin-3-ylacetamide | 1233861-56-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[2-(2-methoxyphenyl)-3-oxo-1H-isoindol-4-yl]-2-pyridin-3-ylacetamide
• CAS: 1233861-56-7
• 化学式: C₂₂H₁₉N₃O₃
• 分子量: 373.411
• InChiKey: XSMCTXJKZDUFKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] ISOINDOLINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS<br/>[FR] ISOINDOLINONE ET ANALOGUES APPARENTÉS COMME MODULATEURS DE SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2010077686A1

  公开（公告）日：2010-07-08

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

  本文提供了新颖的调节sirtuin的化合物及其使用方法。这些调节sirtuin的化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和紊乱，包括与老化或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症、潮红以及那些会受益于增加线粒体活性的疾病或紊乱。还提供了含有sirtuin调节化合物与另一治疗剂结合的组合物。
• ISOINDOLINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：Vu Chi B.

  公开号：US20110319411A1

  公开（公告）日：2011-12-29

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新型的调节sirtuin的化合物及其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，以及治疗和/或预防各种疾病和疾病，包括与衰老或压力有关的疾病或疾病，糖尿病，肥胖症，神经退行性疾病，心血管疾病，血液凝块病，炎症，癌症和/或潮红，以及需要增加线粒体活性的疾病或疾病。还提供了包含sirtuin调节化合物与另一种治疗剂的组合物。