5,6-Diphenyl-3-morpholinon | 5196-97-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 5,6-Diphenyl-3-morpholinon
• 英文别名: 5,6-diphenyl-morpholin-3-one；5,6-diphenylmorpholin-3-one
• CAS: 5196-97-4
• 化学式: C₁₆H₁₅NO₂
• 分子量: 253.301
• InChiKey: UIMBPSRHBSCBJU-UHFFFAOYSA-N

物化性质

• 熔点：
  182-183 °C
• 沸点：
  468.9±45.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：EP1856123A2

  公开（公告）日：2007-11-21
• HETEROARYL ACID MORPHOLINONE COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Amgen Inc.

  公开号：EP2970237B1

  公开（公告）日：2017-09-27
• [EN] METHOD OF IDENTIFYING INHIBITORS OF CDC25<br/>[FR] PROCEDE D'IDENTIFICATION D'INHIBITEURS DE CDC25
  申请人：BASF AG

  公开号：WO2001027077A2

  公开（公告）日：2001-04-19

  The present application relates to compounds of the fornula (VII), wherein the substituents R1-R5, X and Y are as defined in the description and to compounds of formula (VIII) or formula (IX) and when R3 is in the ortho position to X, R?3 and R4¿ are taken together with the atoms to which are each attached to form an aromatic heterocyclic ring. The application further relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.
• [EN] SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF<br/>[FR] INHIBITEURS DE MDM2, SOUS FORME DE PETITES MOLECULES ET UTILISATIONS DE CES DERNIERS
  申请人：UNIV MICHIGAN

  公开号：WO2006091646A2

  公开（公告）日：2006-08-31

  [EN] The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
  [FR] La présente invention concerne de petites molécules qui font office d'inhibiteurs de l'interaction entre p53 et MDM2. Cette invention porte également sur l'utilisation de ces composés pour inhiber la croissance cellulaire, induire la mort cellulaire, induire l'arrêt du cycle cellulaire et/ou pour sensibiliser des cellules à un ou plusieurs agents additionnels.