1,1-dimethylethyl {(3R,4S)-3-hydroxy-1-[2-(2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl]-4-piperidinyl}carbamate | 1173897-79-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,1-dimethylethyl {(3R,4S)-3-hydroxy-1-[2-(2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl]-4-piperidinyl}carbamate
• 英文别名: tert-butyl N-[(3R,4S)-3-hydroxy-1-[2-(2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]carbamate
• CAS: 1173897-79-4
• 化学式: C₂₀H₂₈N₄O₄
• 分子量: 388.467
• InChiKey: SAHBEWRDEIVTSL-DOTOQJQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  95
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] NAPHTHYRIDIN-2 (1 H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS<br/>[FR] COMPOSÉS NAPHTHYRIDINE-2(1H)-ONE UTILES COMME ANTIBACTÉRIENS
  申请人：GLAXO GROUP LTD

  公开号：WO2010081874A1

  公开（公告）日：2010-07-22

  Compounds of Formula (I) wherein substituents R1, R2 and R5 are as defined, and Ar represents substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, furanyl, imidazolyl and thiophenyl substituted by a hydroxyalkyl substituent and an optional other substituent; compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

  式（I）中的化合物，其中取代基R1、R2和R5如定义，并且Ar代表被羟基烷基取代和可选其他取代基取代的取代苯基、吡啶基、吡啶并嗪基、嘧啶基、吡嗪基、噻唑基、呋喃基、咪唑基和噻吩基；包含它们的组合物，它们在治疗中的用途，包括它们作为抗菌剂的用途，例如在结核病治疗中的用途，以及这类化合物的制备方法。
• NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS
  申请人：ALEMPARTE-GALLARDO Carlos

  公开号：US20110319424A1

  公开（公告）日：2011-12-29

  Compounds of Formula (I), wherein substituents R 1 , R 2 and R 5 are as defined, and Ar represents substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, furanyl, imidazolyl and thiophenyl; compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

  本发明提供了化学式(I)的化合物，其中取代基R1、R2和R5如定义所述，Ar代表取代的苯基、吡啶基、吡嗪基、嘧啶基、吡咯嗪基、噻唑基、呋喃基、咪唑基和噻吩基；含有它们的组合物，它们在治疗中的使用，包括它们作为抗菌剂的使用，例如在结核病的治疗中，以及制备这种化合物的方法。
• NAPHTHYRIDIN-2 (1 H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS
  申请人：Alemparte-Gallardo Carlos

  公开号：US20120115899A1

  公开（公告）日：2012-05-10

  Compounds of Formula (I), wherein substituents R 1 , R 2 and R 5 are as defined, and Ar represents substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, furanyl, imidazolyl and thiophenyl substituted by a hydroxyalkyl substituent and an optional other substituent; compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

  提供化合物I的公式，其中取代基R1、R2和R5如定义所述，Ar代表取代的苯基、吡啶基、吡嗪基、嘧啶基、吡咯嗪基、噻唑基、呋喃基、咪唑基和噻吩基，取代一个羟基烷基取代基和一个可选的其他取代基；提供包含它们的组合物，它们在治疗中的使用，包括它们作为抗菌剂的使用，例如用于结核病的治疗，并提供制备这种化合物的方法。
• NAPHTHYRIDIN-2(1H)-ONE COMPOUNDS USEFUL AS ANTIBACTERIALS
  申请人：Glaxo Group Limited

  公开号：EP2379554B1

  公开（公告）日：2015-11-11
• US8318940B2
  申请人：——

  公开号：US8318940B2

  公开（公告）日：2012-11-27