6-(2-Imidazo[2,1-b]thiazol-6-ylethyl)-4-morpholino-7H-pyrrolo[3,4-b]pyridin-5-one | 1417186-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 6-(2-Imidazo[2,1-b]thiazol-6-ylethyl)-4-morpholino-7H-pyrrolo[3,4-b]pyridin-5-one
• 英文别名: 6-(2-imidazo[2,1-b][1,3]thiazol-6-ylethyl)-4-morpholin-4-yl-7H-pyrrolo[3,4-b]pyridin-5-one
• CAS: 1417186-12-9
• 化学式: C₁₈H₁₉N₅O₂S
• 分子量: 369.447
• InChiKey: BZHIFDGBIUANQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  91.2
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
  申请人：Geneste Hervé

  公开号：US20130005705A1

  公开（公告）日：2013-01-03

  The present invention relates to novel carboxamide compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating or controlling medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.

  本发明涉及新型的氨基甲酸酰胺化合物、含有它们的药物组合物及其在治疗中的应用。这些化合物具有宝贵的治疗特性，特别适用于治疗或控制神经疾病和精神疾病，用于改善与这些疾病相关的症状，并用于降低这些疾病的风险。
• US9938269B2
  申请人：——

  公开号：US9938269B2

  公开（公告）日：2018-04-10
• [EN] NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A<br/>[FR] NOUVEAUX COMPOSÉS INHIBITEURS DE LA PHOSPHODIESTÉRASE DE TYPE 10A
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2013000994A1

  公开（公告）日：2013-01-03

  The present invention relates to novel carboxamide compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating or controlling medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.