(RS)-S-{3-[({6-bromo-4-[(cyclopropylmethyl)amino]quinazolin-7-yl}oxy)methyl]-phenyl}-N-(ethoxycarbonyl)-S-methylsulphoximide | 1173710-74-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (RS)-S-{3-[({6-bromo-4-[(cyclopropylmethyl)amino]quinazolin-7-yl}oxy)methyl]-phenyl}-N-(ethoxycarbonyl)-S-methylsulphoximide
• 英文别名: ethyl N-[[3-[[6-bromo-4-(cyclopropylmethylamino)quinazolin-7-yl]oxymethyl]phenyl]-methyl-oxo-lambda6-sulfanylidene]carbamate；ethyl N-[[3-[[6-bromo-4-(cyclopropylmethylamino)quinazolin-7-yl]oxymethyl]phenyl]-methyl-oxo-λ6-sulfanylidene]carbamate
• CAS: 1173710-74-1
• 化学式: C₂₃H₂₅BrN₄O₄S
• 分子量: 533.446
• InChiKey: VTHXNRACEOHZEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNO-MODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS
  申请人：NGUYEN Duy

  公开号：US20090186911A1

  公开（公告）日：2009-07-23

  The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.

  本发明涉及公式（I）的磺氧胺取代的喹唑啉衍生物，其制备方法以及作为治疗各种疾病的药物的用途。
• SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2247579A1

  公开（公告）日：2010-11-10
• US7863283B2
  申请人：——

  公开号：US7863283B2

  公开（公告）日：2011-01-04
• [EN] SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS<br/>[FR] DÉRIVÉS DE QUINAZOLINE SUBSTITUÉE PAR UNE SULFOXIMINE EN TANT QU'IMMUNOMODULATEURS, LEUR PRÉPARATION ET LEUR UTILISATION EN TANT QUE MÉDICAMENTS
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2009089851A1

  公开（公告）日：2009-07-23

  The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I) processes for their preparation and their use as a medicament for the treatment of various diseases.