N-isoquinolin-5-ylazepane-1-carboxamide | 1036740-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-isoquinolin-5-ylazepane-1-carboxamide
• CAS: 1036740-30-3
• 化学式: C₁₆H₁₉N₃O
• 分子量: 269.346
• InChiKey: RYJHWHCZRGBGBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ROCK INHIBITORS AND USES THEREOF
  申请人：Sebti Said M.

  公开号：US20090318684A1

  公开（公告）日：2009-12-24

  The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inhibit Rho-protein associated kinase function. Compounds of the invention include piperazinyl pyridines, piperazinylmethyl pyridines, piperazinyl ureas and carbamates, piperazinyl pyridines and quinoilines (including isoquinliones) as well as piperazinyl (including piperazinylmethyl) pyridines and quinolines (including isoquinolines). Compounds of the invention disrupt Rho-kinase activation and function and significantly inhibit tumor cell growth and induce tumor cell death.
• US8993760B2
  申请人：——

  公开号：US8993760B2

  公开（公告）日：2015-03-31