N-[4-(3,4-dihydro-2H-quinolin-1-yl)-phenylmethyl]-6-(2,3-dimethoxy-benzylamino)-pyrimidine-4-carboxylic acid amide | 486436-94-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[4-(3,4-dihydro-2H-quinolin-1-yl)-phenylmethyl]-6-(2,3-dimethoxy-benzylamino)-pyrimidine-4-carboxylic acid amide
• 英文别名: N-[[4-(3,4-dihydro-2H-quinolin-1-yl)phenyl]methyl]-6-[(2,3-dimethoxyphenyl)methylamino]pyrimidine-4-carboxamide
• CAS: 486436-94-6
• 化学式: C₃₀H₃₁N₅O₃
• 分子量: 509.608
• InChiKey: BYIVSPVLAIOKIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  88.6
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Combination of MTP inhibitors or apoB-secretion inhibitors with fibrates for use as pharmaceuticals
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US20030162788A1

  公开（公告）日：2003-08-28

  The invention relates to the use of fibrates for lowering the liver toxicity of MTP inhibitors as well as pharmaceutical compositions containing an MTP inhibitor and a fibrate.

  本发明涉及使用纤维酸衍生物来降低MTP抑制剂对肝脏的毒性，以及包含MTP抑制剂和纤维酸衍生物的药物组合物。
• Heteroarylcarboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US20030073836A1

  公开（公告）日：2003-04-17

  A compound of formula 1 wherein: A a , R a , X 1 to X 4 , Het, and R 5 to R 7 are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

  根据权利要求1中定义的Aa、Ra、X1至X4、Het和R5至R7，本发明的化合物公式1包括这些化合物的同分异构体和盐，尤其是具有生理活性的盐，它们是微囊体甘油三酯转移蛋白（MTP）的有效抑制剂，含有这些化合物的药物及其用途，以及这些化合物的制备方法。