[1-(butane-1-sulfonyl)piperidin-4-yl]diphenylmethanol | 1164112-42-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1-(butane-1-sulfonyl)piperidin-4-yl]diphenylmethanol
• CAS: 1164112-42-8
• 化学式: C₂₂H₂₉NO₃S
• 分子量: 387.543
• InChiKey: CLGDJURZBVYELA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.76
• 重原子数：
  27.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  57.61
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  苯基溴化镁 在 sodium tetrahydroborate 、 potassium carbonate 、 三乙胺 、 环己醇 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 氯仿 、 丙酮 为溶剂， 反应 30.17h， 生成 [1-(butane-1-sulfonyl)piperidin-4-yl]diphenylmethanol
  参考文献：
  名称：

  Synthesis and in vitro antiproliferative activity of diphenyl(sulphonylpiperidin-4-yl)methanol derivatives

  摘要：

  A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-n) were synthesized and characterized by H-1 NMR, LC/MS, FTIR, and elemental analyses. All the synthesized compounds were evaluated for cell proliferation by MTT assay. The antiproliferative effects of the synthesized compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines, namely HeLa cells, HT-29 cells, MCF-7 cells, and HepG-2 cells in comparing the positive and negative control. Among the synthesized compounds, (10b) and (10g) have been identified as potent antiproliferative agents.

  DOI：

  10.1007/s00044-009-9186-8