benzyl(5-fluoro-1H-indazol-3-yl)amine | 1046468-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: benzyl(5-fluoro-1H-indazol-3-yl)amine
• 英文别名: N-benzyl-5-fluoro-1H-indazol-3-amine
• CAS: 1046468-23-8
• 化学式: C₁₄H₁₂FN₃
• 分子量: 241.268
• InChiKey: AFNHHPHDMYJTPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 肼 作用下， 以 二甲基亚砜 为溶剂， 以70%的产率得到benzyl(5-fluoro-1H-indazol-3-yl)amine
  参考文献：
  名称：

  An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles

  摘要：

  A non-acidic procedure for the preparation of 3-aminoindazoles and 3-amino-7-azaindazoles from 2-fluoroaryl carboxylic acids is reported. The synthesis starts from readily available starting materials and uses mild and practical reaction conditions in a three-step overall procedure. Products were isolated for a number of examples, but yields varied significantly depending on electronic nature of the substituents. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.100

文献信息

• An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles
  作者：Michael J. Burke、Brian M. Trantow

  DOI：10.1016/j.tetlet.2008.05.100

  日期：2008.7

  A non-acidic procedure for the preparation of 3-aminoindazoles and 3-amino-7-azaindazoles from 2-fluoroaryl carboxylic acids is reported. The synthesis starts from readily available starting materials and uses mild and practical reaction conditions in a three-step overall procedure. Products were isolated for a number of examples, but yields varied significantly depending on electronic nature of the substituents. (c) 2008 Elsevier Ltd. All rights reserved.