| 1612794-35-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1612794-35-0
• 化学式: C₂₂H₁₆O₂
• 分子量: 312.368
• InChiKey: CULCENRIRHBHFV-BJMVGYQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.57
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  30.21
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  、 N-(4-溴苯基)马来酰亚胺 在 奎宁胺 、 水杨酸 作用下， 以 四氢呋喃 为溶剂， 反应 36.0h， 生成 、
  参考文献：
  名称：

  Asymmetric Dearomatic Diels–Alder Reactions of Diverse Heteroarenes via π-System Activation

  摘要：

  An asymmetric dearomatic Diels-Alder protocol for various heteroarenes, such as benzofuran, benzothiophene, or even furan, has been developed via pi-system activation. This method involves in situ generation of formal trienamine species embedding a heteroaromatic moiety, and an array of chiral fused frameworks with high molecular complexity and skeletal diversity were efficiently constructed in good to excellent stereoselectivity by the catalysis of a cinchona-based primary amine.

  DOI：

  10.1021/ol501217u
• 作为产物：
  描述：

  苯并[b]呋喃-2-甲醛 在 sodium 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  Asymmetric Dearomatic Diels–Alder Reactions of Diverse Heteroarenes via π-System Activation

  摘要：

  An asymmetric dearomatic Diels-Alder protocol for various heteroarenes, such as benzofuran, benzothiophene, or even furan, has been developed via pi-system activation. This method involves in situ generation of formal trienamine species embedding a heteroaromatic moiety, and an array of chiral fused frameworks with high molecular complexity and skeletal diversity were efficiently constructed in good to excellent stereoselectivity by the catalysis of a cinchona-based primary amine.

  DOI：

  10.1021/ol501217u