(E)-5-chloro-2,2-dimethylhex-3-ene | 1012041-71-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: (E)-5-chloro-2,2-dimethylhex-3-ene
• CAS: 1012041-71-2
• 化学式: C₈H₁₅Cl
• 分子量: 146.66
• InChiKey: LUGXDVCSGDRGKA-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  (3E)-5,5-dimethylhex-3-en-2-ol 在 吡啶 、 三氯化磷 作用下， 生成 (E)-4-chloro-5,5-dimethylhex-2-ene 、 (E)-5-chloro-2,2-dimethylhex-3-ene
  参考文献：
  名称：

  Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs

  摘要：

  Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A(1).

  DOI：

  10.1021/ja800103z

文献信息

• Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs
  作者：Sunghee Son、Gregory C. Fu

  DOI：10.1021/ja800103z

  日期：2008.3.1

  Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A(1).