methyl 1-(naphthalen-2-yl)propan-2-yl phenylcarbonimidodithioate | 1013632-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: methyl 1-(naphthalen-2-yl)propan-2-yl phenylcarbonimidodithioate
• 英文别名: 1-methylsulfanyl-1-(1-naphthalen-2-ylpropan-2-ylsulfanyl)-N-phenylmethanimine
• CAS: 1013632-28-4
• 化学式: C₂₁H₂₁NS₂
• 分子量: 351.536
• InChiKey: VNELUETYUXIAEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  63
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 1-(naphthalen-2-yl)propan-2-yl phenylcarbonimidodithioate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以76%的产率得到1-(naphthalen-2-yl)propane-2-thiol
  参考文献：
  名称：

  Decarboxylative Radical Azidation Using MPDOC and MMDOC Esters

  摘要：

  An efficient radical-mediated decarboxylative azidation of aliphatic carboxylic acids has been developed. The success of this transformation hinges on the use of a new type of thiohydroxamate esters (MPDOC esters). These esters are more stable than the classical Barton esters and less prone to rearrange under radical conditions. In the case of alpha-alkoxy and alpha-amino acids, optimal results are obtained with the even more stable MMDOC esters developed recently by Kim.

  DOI：

  10.1021/ol702832x
• 作为产物：
  描述：

  methyl 2-methyl-3-(naphthalen-2-yl)propanoyloxy(phenyl)carbamodithioate 以 二氯甲烷 为溶剂， 反应 2.0h， 以76%的产率得到methyl 1-(naphthalen-2-yl)propan-2-yl phenylcarbonimidodithioate
  参考文献：
  名称：

  Decarboxylative Radical Azidation Using MPDOC and MMDOC Esters

  摘要：

  An efficient radical-mediated decarboxylative azidation of aliphatic carboxylic acids has been developed. The success of this transformation hinges on the use of a new type of thiohydroxamate esters (MPDOC esters). These esters are more stable than the classical Barton esters and less prone to rearrange under radical conditions. In the case of alpha-alkoxy and alpha-amino acids, optimal results are obtained with the even more stable MMDOC esters developed recently by Kim.

  DOI：

  10.1021/ol702832x

文献信息

• Decarboxylative Radical Azidation Using MPDOC and MMDOC Esters
  作者：Erich Nyfeler、Philippe Renaud

  DOI：10.1021/ol702832x

  日期：2008.3.1

  An efficient radical-mediated decarboxylative azidation of aliphatic carboxylic acids has been developed. The success of this transformation hinges on the use of a new type of thiohydroxamate esters (MPDOC esters). These esters are more stable than the classical Barton esters and less prone to rearrange under radical conditions. In the case of alpha-alkoxy and alpha-amino acids, optimal results are obtained with the even more stable MMDOC esters developed recently by Kim.