N,N'-bis(3,4-dihydroxybenzyl)urea | 383423-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N,N'-bis(3,4-dihydroxybenzyl)urea
• 英文别名: 1,3-Bis[(3,4-dihydroxyphenyl)methyl]urea
• CAS: 383423-37-8
• 化学式: C₁₅H₁₆N₂O₅
• 分子量: 304.302
• InChiKey: KXJWVCBQUZTWTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  122
• 氢给体数：
  6
• 氢受体数：
  5

文献信息

• 3,4-dihydroxybenzyl-substituted carbonic acid derivatives and the use thereof as antioxidants
  申请人：——

  公开号：US20030139470A1

  公开（公告）日：2003-07-24

  The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuffs and stimulants, to protect cells and tissues from the harmful effects of radicals and reactive oxygen compounds that accelerate aging. The invention further relates to cosmetic and pharmaceutical preparations and to foodstuffs and stimulants that comprises the inventive 3,4-dihydroxybenzyl-substituted carbonic acid derivatives.

  本发明涉及3,4-二羟基苯甲基取代的碳酸衍生物，其制备方法以及它们在抗氧化剂或自由基清除剂中的应用，特别是在化妆品和制药制剂以及食品和兴奋剂中，以保护细胞和组织免受加速衰老的自由基和反应性氧化化合物的有害影响。本发明还涉及包含创新的3,4-二羟基苯甲基取代的碳酸衍生物的化妆品和制药制剂以及食品和兴奋剂。
• Compounds, compositions and methods for the treatment of inflammatory diseases
  申请人：Sanders J. Virginia

  公开号：US20070208087A1

  公开（公告）日：2007-09-06

  The use of a composition comprising a compound: where R is a C 1 -C 10 alkylene group, in which, when the number of carbon atoms is at least 2, there are optionally 1 or 2 non-adjacent double bonds; 1 to 3 non-adjacent methylene groups are optionally replaced by NR 1 (where R 1 is H, alkyl, or acyl), O, or S; and 1 or 2 methylene groups are optionally replaced by a carbonyl or hydroxymethylene group for the preparation of a medicament or a pharmaceutical for the treatment of inflammatory diseases.

  使用含有化合物的组合物：其中R是C1-C10烷基基团，当碳原子数至少为2时，可以选则1或2个非相邻的双键；1到3个非相邻的亚甲基团可以被NR1（其中R1为H，烷基或酰基）、O或S替换；并且1或2个亚甲基团可以被羰基或羟甲基基团替换，以制备用于治疗炎症性疾病的药物或制剂。
• Compounds, Compositions and Methods for the Treatment of Inflammatory Diseases
  申请人：Sanders Virginia

  公开号：US20120058998A1

  公开（公告）日：2012-03-08

  A method of inhibiting the inflammatory process, the method comprising administering to a mammal suffering from inflammation a therapeutically effective amount of a pharmaceutical composition comprising a compound where: R is a C 1 -C 10 alkylene group, in which, when the number of carbon atoms is at least 2, there are optionally 1 or 2 non-adjacent double bonds; 1 to 3 non-adjacent methylene groups are optionally replaced by NR 1 (where R 1 is H, alkyl, or acyl), O, or S; and 1 or 2 methylene groups are optionally replaced by a carbonyl or hydroxymethylene group and pharmaceutically acceptable esters or salts of the compounds and wherein the inflammatory process results from a disease selected from the group consisting of ulcerative colitis, endotoxic shock, rheumatoid arthritis, juvenile arthritis, osteoarthritis, psoriasis, Crohn's disease, inflammatory bowel disease, multiple sclerosis, insulin dependent diabetes mellitus, gout, psoriatic arthritis, reactive arthritis, vital or post-viral arthritis and ankylosing spondylarthritis.
• US8754133B2
  申请人：——

  公开号：US8754133B2

  公开（公告）日：2014-06-17