(14βH)-17α-Hydroxy-4-Oestren-3-on | 17554-47-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (14βH)-17α-Hydroxy-4-Oestren-3-on
• 英文别名: 17α-Hydroxy-14β-oestr-4-en-3-on；(14beta, 17alpha)-17-Hydroxyestr-4-en-3-one；17β-hydroxy-(14β,17βH)-estr-4-en-3-one；(8R,9S,10R,13S,14R,17R)-17-hydroxy-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 17554-47-1
• 化学式: C₁₈H₂₆O₂
• 分子量: 274.403
• InChiKey: NPAGDVCDWIYMMC-PZELGXHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 14 Beta, 16, 17-methylene steroids as novel androgens
  申请人：——

  公开号：US20040030165A1

  公开（公告）日：2004-02-12

  Disclosed are androgenic steroids of the (14&bgr;,17&agr;)-17-(hydroxymethyl) type. The invention relates to an improvement hereof, which is based on the presence of a &x3B2;-oriented, annellated cyclopropyl group which includes carbon atoms 16 and 17 of the steroid skeleton, i.e. a 16,17&bgr;-methylene moiety. These steroids show an unexpectedly high androgenic potency.

  本发明公开了(14&bgr;,17&agr;)-17-(羟甲基)型雄激素类固醇。本发明涉及对这种类固醇的改进，改进的基础是存在一个&x3B2;取向的环丙基，环丙基包括类固醇骨架的碳原子 16 和 17，即一个 16,17&bgr;-亚甲基。这些类固醇具有意想不到的高雄激素效力。
• METHYLENE STEROIDS AS NOVEL ANDROGENS
  申请人：N.V. Organon

  公开号：EP1343806B1

  公开（公告）日：2008-05-28
• 17ALPHA-HYDROXY-14BETA-STEROIDS WITH HORMONAL EFFECT
  申请人：N.V. Organon

  公开号：EP1427748B1

  公开（公告）日：2008-05-14
• US6949531B2
  申请人：——

  公开号：US6949531B2

  公开（公告）日：2005-09-27
• [EN] METHYLENE STEROIDS AS NOVEL ANDROGENS<br/>[FR] STEROIDES DU TYPE 14 DOLLAR G(B),16,17-METHYLENE TENANT LIEU D'ANDROGENES
  申请人：AKZO NOBEL NV

  公开号：WO2002048171A1

  公开（公告）日：2002-06-20

  Disclosed are androgenic steroids of the (14β, 17α)-17-(hydroxymethyl) type. The invention relates to an improvement hereof, which is based on the presence of a β-oriented, annellated cyclopropyl group which includes carbon atoms 16 and 17 of the steroid skeleton, i.e. a 16,17 β-methylene moiety. These steroids show an unexpectedly high androgenic potency.