2-(2,4,6-trimethoxyphenyl)naphthalene | 1040196-78-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2,4,6-trimethoxyphenyl)naphthalene
• CAS: 1040196-78-8
• 化学式: C₁₉H₁₈O₃
• 分子量: 294.35
• InChiKey: JCZWTNHUPSIECH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4,6-三甲氧基苯甲酸 、 2-萘硼酸 在 palladium(II) trifluoroacetate 、 silver carbonate 作用下， 以 二甲基亚砜 为溶剂， 以92%的产率得到2-(2,4,6-trimethoxyphenyl)naphthalene
  参考文献：
  名称：

  Pd催化的Suzuki脱羧反应和芳香族羧酸的正交Cu基O-芳基化反应。

  摘要：

  钯催化的脱羧Suzuki反应和芳香族羧酸的正交Cu基O-芳基化反应已有报道。新的反应可能为某些联芳基和芳族羧酸酯的合成提供替代途径。

  DOI：

  10.1039/c0cc04104a

文献信息

• Palladium-catalyzed decarboxylative coupling of benzoic acid derivatives using hydrazone ligands
  作者：Takashi Mino、Eri Yoshizawa、Kohei Watanabe、Taichi Abe、Kiminori Hirai、Masami Sakamoto

  DOI：10.1016/j.tetlet.2014.04.017

  日期：2014.5

  Palladium-catalyzed decarboxylative coupling of benzoic acid derivatives with arylboroxins gave biaryls using a catalytic amount of Pd(TFA)(2)-hydrazone Id system with Ag2CO3 at 80 degrees C in good yields. We also found that decarboxylative coupling with aryl(trialkoxy)silanes gave biaryls using a Pd(TFA)(2)-hydrazone 1g system with AgF in good yields. 2014 Elsevier Ltd. All rights reserved.
• Copper-Mediated C−H Bond Arylation of Arenes with Arylboronic Acids
  作者：Ikuya Ban、Tomoko Sudo、Tadashi Taniguchi、Kenichiro Itami

  DOI：10.1021/ol8013717

  日期：2008.8.21

  A new copper-mediated cross-coupling of arenes and arylboronic acids is described. Under the influence of Cu(OCOCF3)(2), the C-H bond arylation of electron-rich arenes with arylboronic acids takes place to afford a range of biaryis in good yields. The reaction is selective for cross-coupling; no homocoupling product arising from arenes or arylboronic acids is detected. Multiple C-H bond arylation is possible with indoles and pyrroles furnishing interesting extended pi-systems.