1-Amino-naphthalinsulfonamid-7 | 13261-52-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Amino-naphthalinsulfonamid-7
• 英文别名: 8-amino-naphthalene-2-sulfonic acid amide；8-Amino-naphthalin-2-sulfonsaeure-amid；8-Aminonaphthalene-2-sulfonamide
• CAS: 13261-52-4
• 化学式: C₁₀H₁₀N₂O₂S
• 分子量: 222.268
• InChiKey: XZCXIJGKZSJOAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 磷化氢 、 氢碘酸 、 溶剂黄146 作用下， 生成 1-Amino-naphthalinsulfonamid-7
  参考文献：
  名称：

  Cleve, Chemische Berichte, 1892, vol. 25, p. 2486

  摘要：

  DOI：

文献信息

• Tetrakisazo compound and ink containing the compound
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0645436A1

  公开（公告）日：1995-03-29

  A tetrakisazo compound represented by the following formula (1) in the free acid form: wherein Q₁ and Q₂ independently represent a phenylene or naphthylene group which may be optionally substituted, R₄, R₅ and R₆ independently represent a hydrogen atom, a halogen atom, a hydroxy group, a sulfonic acid group or an amino, alkyl, alkoxy, carbamoyl or sulfamoyl group which may be optionally substituted, m is 0 or 1 and n is 1 or 2, and an ink which comprises the tetrakisazo compound. The ink exhibit excellent properties for ink jet printing.

  游离酸形式的下式（1）所代表的四异氮化合物： 其中，Q₁ 和 Q₂ 各自代表可被任选取代的亚苯基或亚萘基，R₄、R₅ 和 R₆ 各自代表氢原子、卤素原子、羟基、磺酸基或可被任选取代的氨基、烷基、烷氧基、氨基甲酰基或氨基磺酰基，m 为 0 或 1，n 为 1 或 2。这种油墨在喷墨打印方面具有优异的性能。
• 5 alpha-reductase Inhibitors
  申请人：ELI LILLY AND COMPANY

  公开号：EP0703221A1

  公开（公告）日：1996-03-27

  A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5α -reductase. The compounds have the formula wherein R and R¹ both represent hydrogen or combine to form a bond;    R represents hydrogen or C₁-C₃ alkyl;    R³ represents methyl or ethyl;    R⁴ and -X-R⁵ each occupies one of the 7-, 8-and 9-positions;    R⁴ represents hydrogen, halo, methyl or ethyl;    X represents C₁-C₄ alkyl, C₂-C₄ alkenyl, C₂-C₄ alkynyl, a bond, -SO-, -SO₂-, -CO-Y-(CH₂)n-, -Y-CO-(CH₂)n, -CO-, -Z-(CH₂)n-, or -SO₃-; wherein X groups which are not symmetrical may be in either orientation;    Y represents -S-, -O-, or -NH-;    Z represents -O- or -S-;    n represents 0-3;    R⁵ represents phenyl, naphthalenyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, anthracenyl, acenaphthalenyl, thiazolyl, benzimidazolyl, indazolyl, thiophenyl, phenanthrenyl, quinolinyl, fluorenyl, isoquinolinyl, indanyl, benzopyranyl, indolyl, benzisoquinolinyl, benzindolyl, benzothiazolyl, benzothiophenyl, quinoxalinyl, benzoxazolyl, tetrazolyl, naphthothiazolyl, quinazolinyl, thiazolopyridinyl, pyridazinoquinazolinyl, benzisothiazolyl, benzodioxolyl, benzodioxinyl, diphenylmethyl or triphenylmethyl;    the above R⁵ groups are unsubstituted or substituted with 1-3 groups chosen from the group consisting of halo, trifluoromethyl, trifluoroethoxy, C₁-C₄ alkyl, trifluoromethoxy, hydroxy, C₁-C₃ alkoxy, nitro, C₁-C₃ alkylthio, C₁-C₆ alkanoyl, phenyl, oxo, phenoxy, phenylthio, C₁-C₃ alkylsulfinyl, C₁-C₃ alkylsulfonyl, cyano, amino, C₁-C₃ alkylamino, diphenylmethylamino, triphenylmethylamino, benzyloxy, benzylthio, (mono-halo, nitro or CF₃)benzyl(oxy or thio), di(C₁-C₃ alkyl, C₃-C₆ cycloalkyl, or C₄-C₈ cycloalkylalkyl)amino, (mono-C₁-C₃ alkyl, C₁-C₃ alkoxy or halo)-(phenyl, phenoxy, phenylthio, phenylsulfonyl or phenoxysulfonyl), C₂-C₆ alkanoylamino, benzoylamino, diphenylmethylamino(C₁-C₃ alkyl), aminocarbonyl, C₁-C₃ alkylaminocarbonyl, di(C₁-C₃ alkyl)aminocarbonyl, halo-C₁-C₆ alkanoyl, aminosulfonyl, C₁-C₃ alkylaminosulfonyl, di(C₁-C₃ alkyl)aminosulfonyl, phenyl(oxy or thio)(C₁-C₃ alkyl), (halo, C₁-C₃ alkyl or C₁-C₃ alkoxy)phenyl(oxy or thio) (C₁-C₃ alkyl), benzoyl, or (amino, C₁-C₃ alkylamino or di(C₁-C₃ alkyl)amino)(C₁-C₃ alkyl);    or an above R⁵ group is substituted with a morpholino(C₁-C₃ alkyl) group, a phenyl(C₁-C₃ alkyl)piperidinyl group, a phenyl(C₁-C₃ alkyl)-Piperidinylaminocarbonyl group, a C₂-C₆ alkanoylaminothiophenyl group, or a (amino, C₁-C₃ alkylamino or di(C₁-C₃ alkyl)amino)naphthalenylsulfonylamino group;    or R⁵ is a perhalophenyl group;    or a pharmaceutically acceptable salt thereof.

  一系列苯并喹啉-3-酮类化合物是治疗 I 型和 II 型 5α 还原酶所致疾病的有效药物。这些化合物的化学式为 其中 R 和 R¹ 均代表氢或结合成键； R 代表氢或 C₁-C₃ 烷基； R³ 代表甲基或乙基； R⁴ 和 -X-R⁵ 各占 7、8 和 9 位中的一个； R⁴ 代表氢、卤素、甲基或乙基； X 代表 C₁-C₄ 烷基、C₂-C₄ 烯基、C₂-C₄ 炔基、键、-SO-、-SO₂-、-CO-Y-(CH₂)n-、-Y-CO-(CH₂)n-、-CO-、-Z-(CH₂)n- 或-SO₃-；其中非对称的 X 基团可以是任一取向； Y 代表-S-、-O-或-NH-； Z 代表-O-或-S-； n 代表 0-3； R⁵ 代表苯基、萘基、吡啶基、吡嗪基、哒嗪基、嘧啶基、蒽基、苊烯基、噻唑基、苯并咪唑基、吲唑基、噻吩基、菲基、喹啉基、芴基、异喹啉基、茚基、苯并吡喃基、吲哚基苯并异喹啉基、苯并吲哚基、苯并噻唑基、苯并噻吩基、喹喔啉基、苯并噁唑基、四唑基、萘并噻唑基、喹唑啉基、噻唑并吡啶基、哒嗪并喹唑啉基、苯并异噻唑基、苯并二噁唑基、苯并二噁嗪基、二苯基甲基或三苯甲基； 上述 R⁵ 基团未被取代或被 1-3 个基团取代，这些基团选自卤代、三氟甲基三氟乙氧基、C₁-C₄ 烷基、三氟甲氧基、羟基、C₁-C₃ 烷氧基、硝基、C₁-C₃ 烷硫基、C₁-C₆ 烷酰基、苯基、氧代、苯氧基C₁-C₃烷基硫基、C₁-C₃烷基磺酰基、氰基、氨基、C₁-C₃烷基氨基、二苯基甲基氨基、三苯基甲基氨基、苄氧基、苄硫基、（单卤代、硝基或 CF₃）苄基（氧基或硫代）、二（C₁-C₃ 烷基、C₃-C₆ 环烷基或 C₄-C₈环烷基烷基）氨基、(单-C₁-C₃烷基、C₁-C₃烷氧基或卤代)-(苯基、苯氧基、苯硫基、苯磺酰基或苯氧基磺酰基)、C₂-C₆烷酰氨基、苯甲酰氨基、二苯基甲基氨基（C₁-C₃ 烷基），氨基羰基，C₁-C₃ 烷基氨基羰基，二（C₁-C₃ 烷基）氨基羰基，卤代-C₁-C₆ 烷酰基、氨基磺酰基、C₁-C₃ 烷基氨基磺酰基、二(C₁-C₃ 烷基)氨基磺酰基、苯基(氧基或硫代)(C₁-C₃ 烷基)、(卤代、C₁-C₃烷基或C₁-C₃烷氧基)苯基(氧基或硫代)(C₁-C₃烷基)、苯甲酰基或(氨基、C₁-C₃烷基氨基或二(C₁-C₃烷基)氨基)(C₁-C₃烷基)； 或上述 R⁵ 基团被吗啉基(C₁-C₃烷基)、苯基(C₁-C₃烷基)哌啶基、苯基(C₁-C₃烷基)-哌啶氨基羰基取代、C₂-C₆烷酰氨基噻吩基团，或 (氨基、C₁-C₃烷基氨基或二(C₁-C₃烷基)氨基)萘磺酰氨基基团； 或 R⁵ 是高卤苯基； 或其药学上可接受的盐。
• Use of benzoquinolin-3-ones for the treatment and prevention of prostatic cancer
  申请人：ELI LILLY AND COMPANY

  公开号：EP0733365A2

  公开（公告）日：1996-09-25

  A series of benzoquinolin-3-ones as defined in Claim 1, are pharmaceuticals effective in preventing the development of prostatic cancer, or preventing or treating the metastasis to bone of prostatic cancer.

  2.如权利要求1所定义的一系列苯并喹啉-3-酮，是有效预防前列腺癌发展或预防或治疗前列腺癌骨转移的药物。
• Cleve, Chemische Berichte, 1888, vol. 21, p. 3265
  作者：Cleve

  DOI：——

  日期：——
• WATER-SOLUBLE NEAR-INFRARED ABSORBING COLORING MATTERS AND AQUEOUS INKS CONTAINING SAME
  申请人：Hirota Koji

  公开号：US20110123784A1

  公开（公告）日：2011-05-26

  Coloring matters represented by general formula (1) or salts thereof are simply provided at a low cost as water-soluble coloring matters which exhibit absorption in the near-infrared region. Further, aqueous ink compositions which contain the coloring matters and have excellent storage stability are also provided. In general formula (1), Nc is optionally substituted naphthalocyanine; M is a metal oxide or the like; R 1 and R 2 are each independently hydrogen or the like; A is a crosslinking group; X and Y are each independently substituted arylamino or the like; k is more than 0 but up to 12 (on average); p is 0 to less than 12; the sum of k and p is more than 0 but up to 12; and any two or the three of R 1 , R 2 and A may be united to form a ring.