(3R,4R)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo<2.2.1>heptane hydrochloride | 133520-40-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3R,4R)-3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo<2.2.1>heptane hydrochloride
• 英文别名: (3R,4R)-3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane Hydrochloride；5-[(3R,4R)-1-azabicyclo[2.2.1]heptan-3-yl]-3-cyclopropyl-1,2,4-oxadiazole;hydrochloride
• CAS: 133520-40-8
• 化学式: C₁₁H₁₅N₃O*ClH
• 分子量: 241.721
• InChiKey: UVYJWRPBNKHCGJ-OZZZDHQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.79
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• An oxadiazole and its salts, their use in treating dementia, their preparation and formulations
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0398629A2

  公开（公告）日：1990-11-22

  The compound (3R, 4R)-3-(3-cyclopropyl-1,2,4-­oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane and its salts behave as a functionally selective muscarinic agonist and are useful in the treatment of neurological and mental disorders, preferably in a pharmaceutical formulation comprising the active compound in association with a pharmaceutically acceptable carrier. The compound can be prepared by methods analogous to those known in the art via suitable chiral intermediates and cyclopropyl carboxamide oxime.

  化合物(3R, 4R)-3-(3-环丙基-1,2,4-恶二唑-5-基)-1-氮杂双环[2.2.1]庚烷及其盐类具有功能选择性毒蕈碱激动剂的作用，可用于治疗神经和精神疾病。该化合物的制备方法类似于本领域已知的方法，通过合适的手性中间体和环丙基羧酰胺肟。
• US5106853A
  申请人：——

  公开号：US5106853A

  公开（公告）日：1992-04-21