3-Morpholin-4-ylnaphthalen-1-ol | 1364301-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-Morpholin-4-ylnaphthalen-1-ol
• 英文别名: 3-morpholin-4-ylnaphthalen-1-ol
• CAS: 1364301-90-5
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: YIMIUYMAMNFBEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 3-Chlor-naphthol-(1) 在 tris-(dibenzylideneacetone)dipalladium(0) 、 sodium t-butanolate 、 2-二-叔丁膦基-2',4',6'-三异丙基联苯 作用下， 以 甲苯 为溶剂， 反应 16.0h， 以80%的产率得到3-Morpholin-4-ylnaphthalen-1-ol
  参考文献：
  名称：

  Synthesis of functionalized 3-chloro-1-naphthols via Friedel–Crafts acylation of vinyl chlorides

  摘要：

  Friedel-Crafts type cyclization of vinyl chlorides was developed into a general method for the synthesis of functionalized naphthols. The chloro functional group contained within these products allowed for further elaboration via cross-coupling reactions, leading to increased structural complexity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.01.011

文献信息

• Synthesis of functionalized 3-chloro-1-naphthols via Friedel–Crafts acylation of vinyl chlorides
  作者：Xin Linghu、Mark McLaughlin、Cheng-yi Chen、Robert A. Reamer、Lisa Dimichele、Ian W. Davies

  DOI：10.1016/j.tetlet.2012.01.011

  日期：2012.3

  Friedel-Crafts type cyclization of vinyl chlorides was developed into a general method for the synthesis of functionalized naphthols. The chloro functional group contained within these products allowed for further elaboration via cross-coupling reactions, leading to increased structural complexity. (C) 2012 Elsevier Ltd. All rights reserved.