(3R,4aS,5S,10aR)-5-hydroxydihydrofusarubin D | 1335246-34-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: (3R,4aS,5S,10aR)-5-hydroxydihydrofusarubin D
• 英文别名: (3R,4aS,5S,10aR)-3,5,6,9-tetrahydroxy-7-methoxy-3-methyl-4,4a,5,10a-tetrahydro-1H-benzo[g]isochromen-10-one
• CAS: 1335246-34-8
• 化学式: C₁₅H₁₈O₇
• 分子量: 310.304
• InChiKey: UHLYLCLJRKLDOP-IKRVUARBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (3R,4aS,5S,10aR)-5-hydroxydihydrofusarubin D 在 吡啶 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 34.0h， 生成
  参考文献：
  名称：

  Dihydronaphthalenones from endophytic fungus Fusarium sp. BCC14842

  摘要：

  Eleven new dihydronaphthalenones 1-11, together with five known compounds; 5-hydroxydihydrofusarubin C (12), javanicin, bostrycoidin, anhydrofusarubin, and 3-O-methylfusarubin, were isolated from the endophytic fungus Fusarium sp. BCC14842. Structures were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. Javanicin, 3-O-methylfusarubin, compounds 3 and 7 exhibited antimycobacterial and cytotoxic activities. Javanicin also displayed antifungal activity with IC50 of 6.16 mu g/mL, while compounds 2, 4, 5, 8, and 12 showed only cytotoxic activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.078

文献信息

• Dihydronaphthalenones from endophytic fungus Fusarium sp. BCC14842
  作者：Jittra Kornsakulkarn、Kulvadee Dolsophon、Nattawut Boonyuen、Tanapong Boonruangprapa、Pranee Rachtawee、Samran Prabpai、Palangpon Kongsaeree、Chawanee Thongpanchang

  DOI：10.1016/j.tet.2011.07.078

  日期：2011.9

  Eleven new dihydronaphthalenones 1-11, together with five known compounds; 5-hydroxydihydrofusarubin C (12), javanicin, bostrycoidin, anhydrofusarubin, and 3-O-methylfusarubin, were isolated from the endophytic fungus Fusarium sp. BCC14842. Structures were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. Javanicin, 3-O-methylfusarubin, compounds 3 and 7 exhibited antimycobacterial and cytotoxic activities. Javanicin also displayed antifungal activity with IC50 of 6.16 mu g/mL, while compounds 2, 4, 5, 8, and 12 showed only cytotoxic activity. (C) 2011 Elsevier Ltd. All rights reserved.