5-Chloro-2-methyl-4-thiocyanato-phenol | 600135-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-Chloro-2-methyl-4-thiocyanato-phenol
• 英文别名: (2-Chloro-4-hydroxy-5-methylphenyl) thiocyanate
• CAS: 600135-38-4
• 化学式: C₈H₆ClNOS
• 分子量: 199.661
• InChiKey: IEYBQRZTYDTMSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds that modulate PPAR activity and methods of preparation
  申请人：——

  公开号：US20030207924A1

  公开（公告）日：2003-11-06

  This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses methods for making the disclosed compounds.

  这项发明揭示了能够改变PPAR活性的化合物。该发明还揭示了这些化合物的药用盐、包含这些化合物或其盐的药用组合物，以及将它们用作治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。本发明还揭示了制备所述化合物的方法。
• Compounds that modulate PPAR activity and methods for their preparation
  申请人：——

  公开号：US20030225158A1

  公开（公告）日：2003-12-04

  This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of supressing appetite and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.

  该发明揭示了可以改变PPAR活性的化合物。该发明还揭示了这些化合物的药用可接受盐、含有这些化合物或其盐的药用可接受组合物，以及将它们用作治疗或预防哺乳动物的失脂血症、高胆固醇血症、肥胖症、进食障碍、高血糖、动脉粥样硬化、高甘油三酯血症、高胰岛素血症和糖尿病的治疗剂的方法，以及在哺乳动物中抑制食欲和调节瘦素水平的方法。本发明还揭示了制备所述化合物的方法。
• THIAZOLE AND OXAZOLE DERIVATIVES WHICH MODULATE PPAR ACTIVITY
  申请人：Warner-Lambert Company LLC

  公开号：EP1482935A1

  公开（公告）日：2004-12-08
• COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION
  申请人：WARNER-LAMBERT COMPANY LLC

  公开号：EP1494989A2

  公开（公告）日：2005-01-12
• US6964983B2
  申请人：——

  公开号：US6964983B2

  公开（公告）日：2005-11-15