methyl (2E)-2-[(8R,9S,10R,13S,14S,17R)-2'-methoxy-2',13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5'-1,3-dioxolane]-4'-ylidene]acetate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: methyl (2E)-2-[(8R,9S,10R,13S,14S,17R)-2'-methoxy-2',13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5'-1,3-dioxolane]-4'-ylidene]acetate
• 化学式: C₂₅H₃₄O₆
• 分子量: 430.5
• InChiKey: KCQHQCDHFVGNMK-DEIKBOPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Methods and compositions for the treatment of cancer cachexia
  申请人：Ohio State Innovation Foundation

  公开号：US11529323B2

  公开（公告）日：2022-12-20

  In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.

  在一个方面，本公开涉及治疗癌症恶病质的方法和组合物。在另一个方面，组合物是一种药物组合物，包含I/IIB类HDAC抑制剂和雄激素。在更进一步的方面，治疗方法包括向已被诊断为癌症恶病质的受试者或患者施用I/IIB类HDAC抑制剂和雄激素。在某些方面，I/IIB类HDAC抑制剂是一种称为AR-42的化合物。
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER CACHEXIA
  申请人：Ohio State Innovation Foundation

  公开号：US20200289438A1

  公开（公告）日：2020-09-17

  In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER CACHEXIA<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DE LA CACHEXIE CANCÉREUSE
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2019055687A1

  公开（公告）日：2019-03-21

  In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class l/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class l/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class l/IIB HDAC inhibitor is a compound known as AR-42.