{(2Z)-3-[(1R)-3-chloro-1-phenylpropyl]-5-fluoro-1-propyl-1,3-dihydro-2H-benzimidazol-2-ylidene}cyanamide | 929565-53-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: {(2Z)-3-[(1R)-3-chloro-1-phenylpropyl]-5-fluoro-1-propyl-1,3-dihydro-2H-benzimidazol-2-ylidene}cyanamide
• CAS: 929565-53-7
• 化学式: C₂₀H₂₀ClFN₄
• 分子量: 370.857
• InChiKey: DLLYLWGBISCBQM-BJUXRVGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.59
• 重原子数：
  26.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.01
• 氢给体数：
  0.0
• 氢受体数：
  4.0

文献信息

• Substituted propylamine derivatives and methods of their use
  申请人：McComas Cameron Casey

  公开号：US20070072928A1

  公开（公告）日：2007-03-29

  The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

  本发明涉及具有以下结构的取代丙基胺衍生物：或其药学上可接受的盐，含有这些衍生物的组合物，以及它们用于预防和治疗由单胺再摄取改善的病况的方法，包括但不限于血管运动症状（VMS）、性功能障碍、胃肠和泌尿系统紊乱、慢性疲劳综合征、纤维肌痛综合征、神经系统紊乱，以及由此组合而成的病况，特别是从包括重度抑郁症、血管运动症状、压力和急迫性尿失禁、纤维肌痛综合征、疼痛、糖尿病神经病变等病况中选择的那些病况。
• Luminescence device and display apparatus
  申请人：Canon Kabushiki Kaisha

  公开号：US20030068526A1

  公开（公告）日：2003-04-10

  A luminescence device having a layer containing a metal coordination compound which has a partial structure ML m of formula (2) below and is preferably entirely represented by formula (3) below: ML m L′ n (3), wherein M denotes a metal atom of Ir, Pt, Rh or Pd; represent mutually different bidentate ligands; m is 1 or 2 or 3; n is 0 or 1 or 2 with the proviso that m+n=2 or 3; the partial structure ML m is represented by formula (2) below (wherein B is an isoquinolyl group bonded to the metal M with its N and including a position-1 carbon atom bonded to a cyclic group A which includes the C bonded to the metal M), and the partial structure ML′ n is represented by formula (4), (5) or (6) shown below. There is provided a luminescence device capable of high-efficiency luminescence and long-term high luminance and adapted to red luminescence. 1

  一种发光装置，其包含一个层，其中包含具有部分结构为MLm的金属配位化合物，该配位化合物最好完全由以下公式（3）表示：MLmL'n（3），其中M表示Ir，Pt，Rh或Pd的金属原子；表示互不相同的双齿配体；m为1或2或3；n为0或1或2，但m+n=2或3；部分结构MLm由以下公式（2）表示（其中B是与金属M结合并包括与环状基团A结合的位置1碳原子的异喹啉基团），部分结构ML'n由以下公式（4） ，（5）或（6）表示。提供了一种适用于红色发光的高效发光和长期高亮度的发光装置。
• LUMINESCENCE DEVICE AND DISPLAY APPARATUS
  申请人：Kamatani Jun

  公开号：US20070212570A1

  公开（公告）日：2007-09-13

  A metal coordination compound having the following structure: wherein M′ is Ir or Rh, m′ is 2, and are identical to each other and are represented by a substituted or unsubstituted phenyl isoquinoline ligand. A luminescence device and a display apparatus using this metal coordination is compound are provided.

  一种具有以下结构的金属配位化合物：其中M'为Ir或Rh，m'为2，R1，R2和R3相同且由替代或未替代的苯基异喹啉配体表示。提供了使用此金属配位化合物的发光装置和显示装置。
• LUMINESCENT ELEMENT AND DISPLAY
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1348711A1

  公开（公告）日：2003-10-01

  A luminescence device having a layer containing a metal coordination compound which has a partial structure MLm of formula (2) below and is preferably entirely represented by formula (3) below:         MLmL'n     (3), wherein M denotes a metal atom of Ir, Pt, Rh or Pd; represent mutually different bidentate ligands; m is 1 or 2 or 3; n is 0 or 1 or 2 with the proviso that m+n = 2 or 3; the partial structure MLm is represented by formula (2) below (wherein B is an isoquinolyl group bonded to the metal M with its N and including a position-1 carbon atom bonded to a cyclic group A which includes the C bonded to the metal M), and the partial structure ML'n is represented by formula (4), (5) or (6) shown below. There is provided a luminescence device capable of high-efficiency luminescence and long-term high luminance and adapted to red luminescence.

  一种发光器件，其发光层含有金属配位化合物，该金属配位化合物的部分结构 MLm 如下式（2）所示，最好完全由下式（3）表示： MLmL'n (3)、 其中 M 表示 Ir、Pt、Rh 或 Pd 的金属原子；代表相互不同的双齿配位体；m 为 1 或 2 或 3；n 为 0 或 1 或 2，但 m+n = 2 或 3；部分结构 MLm 由下式(2)表示(其中 B 是与金属 M 结合的异喹啉基团，其 N 包括与环状基团 A 结合的第 1 位碳原子，环状基团 A 包括与金属 M 结合的 C)，部分结构 ML'n 由下式(4)、(5)或(6)表示。本发明提供了一种能够高效发光和长期高亮度并适用于红色发光的发光器件。
• US7147935B2
  申请人：——

  公开号：US7147935B2

  公开（公告）日：2006-12-12