N,N'-bis-(8-nitro-[1]naphthyl)-methylenediamine | 861352-56-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N'-bis-(8-nitro-[1]naphthyl)-methylenediamine
• 英文别名: N,N'-bis-(8-nitro-[1]naphthyl)-methylenediamine；N.N'-Methylen-bis-(8-nitro-naphthylamin-(1))；N,N'-Bis-(8-nitro-[1]naphthyl)-methylendiamin
• CAS: 861352-56-9
• 化学式: C₂₁H₁₆N₄O₄
• 分子量: 388.382
• InChiKey: AAZIOFXXBSMAAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.29
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  110.34
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  1-萘胺 在 乙醇 作用下， 生成 N,N'-bis-(8-nitro-[1]naphthyl)-methylenediamine
  参考文献：
  名称：

  Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats

  摘要：

  This study was conducted to observe the effect of salvianolic acids (SA) on regional cerebral blood flow (rCBF) in rats and on platelet aggregation in vitro and in vivo. Cerebral ischemia was produced in rats by occluding of the right middle cerebral artery, together with the right common carotid artery. rCBF was monitored by H-2 clearance method with a tissue blood-flow meter. Platelet aggregation induced by collagen, ADP, and AA was measured in vitro and in vivo by platelet aggregometer. Doses of SA at 6 and 10 mg/kg body wt. (i.v.) improved rCBF in rats after ischemia, but had no obvious effect on normal rCBF. In vitro, SA inhibited significantly the platelet aggregation induced by collagen, ADP, and AA with IC50 values of 0.197, 2.22 and 3.29 x 10(3) mg/l, respectively. In vivo, doses of SA at 6 and 10 mg/kg body wt. inhibited significantly the platelet aggregation induced by collagen, and SA at 10 mg/kg body wt. inhibited remarkably platelet aggregation induced by ADP. The results suggest that SA could improve rCBF in the ischemic hemisphere and inhibit platelet aggregation in rats.

  DOI：

  10.1078/09447110260571634