[(1S)-1-[(1S,4S,6R,8R,11R,12S,13R,16R,18S,21R)-11,18-dihydroxy-4,6,12,17,17-pentamethyl-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docos-5(10)-en-8-yl]-2-hydroxy-2-methylpropyl] acetate | 942578-77-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(1S)-1-[(1S,4S,6R,8R,11R,12S,13R,16R,18S,21R)-11,18-dihydroxy-4,6,12,17,17-pentamethyl-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docos-5(10)-en-8-yl]-2-hydroxy-2-methylpropyl] acetate
• CAS: 942578-77-0
• 化学式: C₃₂H₅₀O₆
• 分子量: 530.745
• InChiKey: GDUFKVZZRVYNSE-OGUSWUKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  24-O-acetylhydroshengmanol 3-[beta]-D-xylopyranoside(delta16,17)-enol ether 在 potassium phosphate 、 potassium dihydrogenphosphate 、 cellulase 作用下， 以 甲醇 、 水 为溶剂， 反应 72.0h， 以70%的产率得到[(1S)-1-[(1S,4S,6R,8R,11R,12S,13R,16R,18S,21R)-11,18-dihydroxy-4,6,12,17,17-pentamethyl-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docos-5(10)-en-8-yl]-2-hydroxy-2-methylpropyl] acetate
  参考文献：
  名称：

  [EN] COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS
  [FR] COMPOSÉS UTILES POUR LE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS

  摘要：

  如本文所述，本发明提供了用于治疗或减轻神经退行性疾病严重程度的化合物。本发明还提供了治疗或减轻此类疾病严重程度的方法，其中所述方法包括向患者施用本发明的化合物或其组合物。该方法适用于治疗或减轻例如阿尔茨海默病等疾病的严重程度。

  公开号：

  WO2011109657A1

文献信息

• Compounds useful for treating neurodegenerative disorders
  申请人：Findeis A. Mark

  公开号：US20070149491A1

  公开（公告）日：2007-06-28

  As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
• COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS
  申请人：FINDEIS Mark A.

  公开号：US20100144689A1

  公开（公告）日：2010-06-10

  As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
• [EN] COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS<br/>[FR] COMPOSÉS UTILES POUR TRAITER DES MALADIES NEURODÉGÉNÉRATIVES
  申请人：SATORI PHARMACEUTICAL INC

  公开号：WO2008063165A1

  公开（公告）日：2008-05-29

  [EN] As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
  [FR] Telle que décrite ici, la présente invention concerne des composés utiles pour traiter ou diminuer la gravité d'une maladie neurodégénérative. La présente invention concerne également des procédés de traitement ou de diminution de la gravité de telles maladies, ledit procédé consistant à administrer à un patient un composé de la présente invention ou une composition de celui-ci. Ledit procédé est utile pour traiter ou diminuer la gravité, par exemple, de la maladie d'Alzheimer.